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Ai Weiwei – Wikipedia, the free encyclopedia

Posted: September 11, 2016 at 5:26 pm

Ai Weiwei

Ai Weiwei in 2008

Ai Weiwei (Chinese: ; pinyin: i Wiwi, English pronunciation(helpinfo); born 28 August 1957 in Beijing) is a Chinese Contemporary artist and activist. His father’s side’s original surname is Jiang.[1][2][3] Ai collaborated with Swiss architects Herzog & de Meuron as the artistic consultant on the Beijing National Stadium for the 2008 Olympics.[4] As a political activist, he has been highly and openly critical of the Chinese Government’s stance on democracy and human rights. He has investigated government corruption and cover-ups, in particular the Sichuan schools corruption scandal following the collapse of so-called “tofu-dreg schools” in the 2008 Sichuan earthquake.[5] In 2011, following his arrest at Beijing Capital International Airport on 3 April, he was held for 81 days without any official charges being filed; officials alluded to their allegations of “economic crimes”.[6]

Ai’s father was the Chinese poet Ai Qing,[7] who was denounced during the Anti-Rightist Movement. In 1958, the family was sent to a labour camp in Beidahuang, Heilongjiang, when Ai was one year old. They were subsequently exiled to Shihezi, Xinjiang in 1961, where they lived for 16 years. Upon Mao Zedong’s death and the end of the Cultural Revolution, the family returned to Beijing in 1976.[8]

In 1978, Ai enrolled in the Beijing Film Academy and studied animation.[9] In 1978, he was one of the founders of the early avant garde art group the “Stars”, together with Ma Desheng, Wang Keping, Huang Rui, Li Shuang, Zhong Acheng and Qu Leilei. The group disbanded in 1983,[10] yet Ai participated in regular Stars group shows, The Stars: Ten Years, 1989 (Hanart Gallery, Hong Kong and Taipei), and a retrospective exhibition in Beijing in 2007: Origin Point (Today Art Museum, Beijing). In 2014, Ai had a piece named, “Illumination (2014) is housed in the old prison hospital, which looks and feels like the set of a horror film needing no embellishment. For this work, Ai has installed recordings of Tibetan and Native American chants in two psychiatric evaluation rooms, which are tiled chambers created for the observation of mentally ill patients. In these cramped rooms, the rhythmic noisesspiritual, strong, and culturally significantcontrast with the shiny mint-colored walls. The mix of clinical and consciousness is startling, bringing presence to a place that even when it was open and functioning was meant to reduce human to subject. Both haunting and aesthetically delightful, this ambitious exhibition exposes issues of freedom of speech and human rights by creating artistic possibility within and about a broken system. Giving a collective voice to silenced dissidents might just prompt newly sympathetic ears.”[11]

Ai Weiwei came top of Londons paid exhibitions list in 2015 with 4,335 visitors a day at the Royal Academy of Arts.[12]

From 1981 to 1993, he lived in the United States, mostly in New York City.[10] He studied briefly at Parsons School of Design.[14] Ai attended the Art Students League of New York from 1983 to 1986, where he studied with Bruce Dorfman, Knox Martin and Richard Pousette-Dart.[15] He later dropped out of school, and made a living out of drawing street portraits and working odd jobs. During this period, he gained exposure to the works of Marcel Duchamp, Andy Warhol, and Jasper Johns, and began creating conceptual art by altering readymade objects.

Ai befriended beat poet Allen Ginsberg while living in New York, following a chance meeting at a poetry reading where Ginsberg read out several poems about China. Ginsberg had travelled to China and met with Ai’s father, the noted poet Ai Qing, and consequently Ginsberg and Ai became friends.[16]

When he was living in the East Village (from 1983 to 1993), Ai carried a camera with him all the time and would take pictures of his surroundings wherever he was. The resulting collection of photos were later selected and is now known as the New York Photographs.[17]

At the same time, Ai became fascinated by blackjack card games and frequented Atlantic City casinos. He is still regarded in gambling circles as a top tier professional blackjack player according to an article published on blackjackchamp.com.[18][19][20]

In 1993, Ai returned to China after his father became ill.[21] He helped establish the experimental artists’ Beijing East Village and co-published a series of three books about this new generation of artists with Chinese curator Feng Boyi: Black Cover Book (1994), White Cover Book (1995), and Gray Cover Book (1997).[22]

In 1999, Ai moved to Caochangdi, in the northeast of Beijing, and built a studio house his first architectural project. Due to his interest in architecture, he founded the architecture studio FAKE Design, in 2003.[23] In 2000, he co-curated the art exhibition Fuck Off with curator Feng Boyi in Shanghai, China.[24]

Ai is married to artist Lu Qing,[25] and has a son from an extramarital relationship.[26]

In 2005, Ai was invited to start blogging by Sina Weibo, the biggest internet platform in China. He posted his first blog on 19 November. For four years, he “turned out a steady stream of scathing social commentary, criticism of government policy, thoughts on art and architecture, and autobiographical writings.”[27] The blog was later shut down by Sina on 28 May 2009 due to its popularity and Weiwei’s outspoken attitude on events such as the Sichuan earthquake and the Beijing Olympic Games. Since then he has turned to Twitter and writes prolifically over the platform, claiming at least 8 hours online every day. He tweets almost exclusively in Chinese on the account @aiww.[citation needed] As of 31 December 2013, Ai has declared that he would stop tweeting but the account remains active in forms of retweets and Instagram posts.

He also supported the Amnesty petition for Iranian filmmaker Hossein Rajabian and his brother, musician Mehdi Rajabian and released the news on his Twitter pages.[28][bettersourceneeded]

Ten days after the 8.0-magnitude earthquake took place in Sichuan province on 12 May 2008, Ai led a team to survey and film the post-quake conditions in various disaster zones. In response to the government’s lack of transparency in revealing names of students who perished in the earthquake due to substandard school campus constructions, Ai recruited volunteers online and launched a “Citizens’ Investigation” to compile names and information of the student victims. On 20 March 2009, he posted a blog titled “Citizens’ Investigation” and wrote: “To remember the departed, to show concern for life, to take responsibility, and for the potential happiness of the survivors, we are initiating a “Citizens’ Investigation.” We will seek out the names of each departed child, and we will remember them.”[29]

As of 14 April 2009, the list had accumulated 5,385 names.[30] Ai published the collected names as well as numerous articles documenting the investigation on his blog which was shut down by Chinese authorities in May 2009.[31] He also posted his list of names of schoolchildren who died on the wall of his office at FAKE Design in Beijing.[32]

Ai suffered headaches and claimed he had difficulty concentrating on his work since returning from Chengdu in August 2009, where he was beaten by the police for trying to testify for Tan Zuoren, a fellow investigator of the shoddy construction and student casualties in the earthquake. On 14 September 2009, Ai was diagnosed to be suffering internal bleeding in a hospital in Munich, Germany, and the doctor arranged for emergency brain surgery.[33] The cerebral hemorrhage is believed to be linked to the police attack.[34][35]

According to the Financial Times, in an attempt to force Ai to leave the country, two accounts used by him had been hacked in a sophisticated attack on Google in China dubbed Operation Aurora, their contents read and copied; his bank accounts were investigated by state security agents who claimed he was under investigation for “unspecified suspected crimes”.[36]

In November 2010, Ai was placed under house arrest by the Chinese police. He said this was to prevent the planned party marking the demolition of his newly built Shanghai studio.[37]

The building was designed and built by Ai upon encouragement and persuasion from a “high official [from Shanghai]” as part of a new cultural area designated by Shanghai Municipal authorities; Ai would have used it as a studio and to teach architecture courses. But now Ai has been accused of erecting the structure without the necessary planning permission and a demolition notice has been ordered, even though, Ai said, officials had been extremely enthusiastic, and the entire application and planning process was “under government supervision”. According to Ai, a number of artists were invited to build new studios in this area of Shanghai because officials wanted to create a cultural area.[38]

On 3 November 2010, Ai said the government had informed him two months earlier that the newly completed studio would be knocked down because it was illegal. Ai complained that this was unfair, as he was “the only one singled out to have my studio destroyed”. The Guardian reported Ai saying Shanghai municipal authorities were “frustrated” by documentaries on subjects they considered sensitive:[38] two of the better known ones featured Shanghai resident Feng Zhenghu, who lived in forced exile for three months in Narita Airport, Tokyo; another well-known documentary focused on Yang Jia, who murdered six Shanghai police officers.[39]

In the end, the party took place without Weiwei’s presence; his supporters feasted on river crab, an allusion to “harmony”, and a euphemism used to jeer official censorship. Ai was released from house arrest the next day.[40]

Like other activists and intellectuals, Ai was prevented from leaving China in late 2010. Ai suggested that the authorities wanted to prevent him from attending the ceremony in December 2010 to award the 2010 Nobel Peace Prize to fellow dissident Liu Xiaobo.[41] Ai said that he had not been invited to the ceremony, and was attempting to travel to South Korea for a meeting when he was told that he could not leave for reasons of national security.[42]

In the evening of 11 January 2011, Ai’s studio was demolished in a surprise move by the local government.[43][44]

On 3 April 2011, Ai was arrested at Beijing Capital International Airport just before catching a flight to Hong Kong and his studio facilities were searched.[45] A police contingent of approximately 50 officers came to his studio, threw a cordon around it and searched the premises. They took away laptops and the hard drive from the main computer; along with Ai, police also detained eight staff members and Ai’s wife, Lu Qing. Police also visited the mother of Ai’s two-year-old son.[46] While state media originally reported on 6 April that Ai was arrested at the airport because “his departure procedures were incomplete,”[47] the Chinese Ministry of Foreign Affairs said on 7 April that Ai was arrested under investigation for alleged economic crimes.[48] Then, on 8 April, police returned to Ai’s workshop to examine his financial affairs.[49] On 9 April, Ai’s accountant, as well as studio partner Liu Zhenggang and driver Zhang Jingsong, disappeared,[50] while Ai’s assistant Wen Tao has remained missing since Ai’s arrest on 3 April.[51] Ai’s wife said that she was summoned by the Beijing Chaoyang district tax bureau, where she was interrogated about his studio’s tax on 12 April.[52]South China Morning Post reports that Ai received at least two visits from the police, the last being on 31 March three days before his detention apparently with offers of membership to the Chinese People’s Political Consultative Conference. A staff member recalled that Ai had mentioned receiving the offer earlier, “[but Ai] didn’t say if it was a membership of the CPPCC at the municipal or national level, how he responded or whether he accepted it or not.”[52]

On 24 February, amid an online campaign for Middle East-style protests in major Chinese cities by overseas dissidents, Ai posted on his Twitter account: “I didnt care about jasmine at first, but people who are scared by jasmine sent out information about how harmful jasmine is often, which makes me realize that jasmine is what scares them the most. What a jasmine!”[53][54]

Analysts and other activists said Ai had been widely thought to be untouchable, but Nicholas Bequelin from Human Rights Watch suggested that his arrest, calculated to send the message that no one would be immune, must have had the approval of someone in the top leadership.[55] International governments, human rights groups and art institutions, among others, called for Ai’s release, while Chinese officials did not notify Ai’s family of his whereabouts.[56]

State media started describing Ai as a “deviant and a plagiarist” in early 2011.[57] The China Daily subsidiary, the Global Times editorial on 6 April 2011 attacked Ai, saying “Ai Weiwei likes to do something ‘others dare not do.’ He has been close to the red line of Chinese law. Objectively speaking, Chinese society does not have much experience in dealing with such persons. However, as long as Ai Weiwei continuously marches forward, he will inevitably touch the red line one day.”[58] Two days later, the journal scorned Western media for questioning Ai’s charge as a “catch-all crime”, and denounced the use of his political activism as a “legal shield” against everyday crimes. It said “Ai’s detention is one of the many judicial cases handled in China every day. It is pure fantasy to conclude that Ai’s case will be handled specially and unfairly.”[59] Frank Ching expressed in the South China Morning Post that how the Global Times could radically shift its position from one-day to the next was reminiscent of Alice in Wonderland.[60]

Michael Sheridan of The Times suggested that Ai had offered himself to the authorities on a platter with some of his provocative art, particularly photographs of himself nude with only a toy alpaca hiding his modesty with a caption (“grass mud horse covering the middle”). The term possesses a double meaning in Chinese: one possible interpretation was given by Sheridan as: “Fuck your mother, the party central committee”.[61]

Ming Pao in Hong Kong reacted strongly to the state media’s character attack on Ai, saying that authorities had employed “a chain of actions outside the law, doing further damage to an already weak system of laws, and to the overall image of the country.”[57] Pro-Beijing newspaper in Hong Kong, Wen Wei Po, announced that Ai was under arrest for tax evasion, bigamy and spreading indecent images on the internet, and vilified him with multiple instances of strong rhetoric.[62][63] Supporters said “the article should be seen as a mainland media commentary attacking Ai, rather than as an accurate account of the investigation.”[64]

The United States and European Union protested Ai’s detention.[65] The international arts community also mobilised petitions calling for the release of Ai: “1001 Chairs for Ai Weiwei” was organized by Creative Time of New York that calls for artists to bring chairs to Chinese embassies and consulates around the world on 17 April 2011, at 1pm local time “to sit peacefully in support of the artist’s immediate release.”[66][67] Artists in Hong Kong,[68] Germany[68] and Taiwan demonstrated and called for Ai to be released.[69]

One of the major protests by U.S. museums took place on 19 and 20 May when the Museum of Contemporary Art San Diego organized a 24-hour silent protest in which volunteer participants, including community members, media, and museum staff, occupied two traditionally styled Chinese chairs for one-hour periods.[70] The 24-hour sit-in referenced Ai’s sculpture series, Marble Chair, two of which were on view and were subsequently acquired for the Museum’s permanent collection.

The Solomon R. Guggenheim Foundation and the International Council of Museums, which organised petitions, said they had collected more than 90,000 signatures calling for the release of Ai.[71] On 13 April 2011, a group of European intellectuals led by Vclav Havel had issued an open letter to Wen Jiabao, condemning the arrest and demanding the immediate release of Ai. The signatories include Ivan Klma, Ji Grua, Jchym Topol, Elfriede Jelinek, Adam Michnik, Adam Zagajewski, Helmuth Frauendorfer; Bei Ling (Chinese:), a Chinese poet in exile drafted and also signed the open letter.[72]

On 16 May 2011, the Chinese authorities allowed Ai’s wife to visit him briefly. Liu Xiaoyuan, his attorney and personal friend, reported that Wei was in good physical condition and receiving treatment for his chronic diabetes and hypertension; he was not in a prison or hospital but under some form of house arrest.[73]

He is the subject of the 2012 documentary film Ai Weiwei: Never Sorry, directed by American filmmaker Alison Klayman, which received a special jury prize at the 2012 Sundance Film Festival and opened the Hot Docs Canadian International Documentary Festival, North America’s largest documentary festival, in Toronto on 26 April 2012.[74]

On 22 June 2011, the Chinese authorities released Ai from jail after almost three months’ detention on charges of tax evasion.[75] Beijing Fake Cultural Development Ltd. (Chinese: ), a company Ai controlled, had allegedly evaded taxes and intentionally destroyed accounting documents. State media also reports that Ai was granted bail on account of Ai’s “good attitude in confessing his crimes”, willingness to pay back taxes, and his chronic illnesses.[76] According to the Chinese Foreign Ministry, he is prohibited from leaving Beijing without permission for one year.[77][78] Ai’s supporters widely viewed his detention as retaliation for his vocal criticism of the government.[79] On 23 June 2011, professor Wang Yujin of China University of Political Science and Law stated that the release of Ai on bail shows that the Chinese government could not find any solid evidence of Ai’s alleged “economic crime”.[80] On 24 June 2011, Ai told a Radio Free Asia reporter that he was thankful for the support of the Hong Kong public, and praised Hong Kong’s conscious society. Ai also mentioned that his detention by the Chinese regime was hellish (Chinese: ), and stressed that he is forbidden to say too much to reporters.[81]

After his release, his sister gave some details about his detention condition to the press, explaining that he was subjected to a kind of psychological torture: he was detained in a tiny room with constant light, and two guards were set very close to him at all times, and watched him constantly.[82] In November, Chinese authorities were again investigating Ai and his associates, this time under the charge of spreading pornography.[83][84] Lu was subsequently questioned by police, and released after several hours though the exact charges remain unclear.[85][86] In January 2012, in its International Review issue Art in America magazine featured an interview with Ai Weiwei at his home in China. J.J. Camille (the pen name of a Chinese-born writer living in New York), “neither a journalist nor an activist but simply an art lover who wanted to talk to him” had travelled to Beijing the previous September to conduct the interview and to write about his visit to “China’s most famous dissident artist” for the magazine.[87]

On 21 June 2012, Ai’s bail was lifted. Although he is allowed to leave Beijing, the police informed him that he is still prohibited from traveling to other countries because he is “suspected of other crimes,” including pornography, bigamy and illicit exchange of foreign currency.[88][89] Until 2015, he remained under heavy surveillance and restrictions of movement, but continues to criticize through his work.[90][91] In July 2015, he was given a passport and may travel abroad.[92]

In June 2011, the Beijing Local Taxation Bureau demanded a total of over 12 million yuan (US$1.85million) from Beijing Fake Cultural Development Ltd in unpaid taxes and fines,[93][94] and accorded three days to appeal the demand in writing. According to Ai’s wife, Beijing Fake Cultural Development Ltd has hired two Beijing lawyers as defense attorneys. Ai’s family state that Ai is “neither the chief executive nor the legal representative of the design company, which is registered in his wife’s name.”

Offers of donations poured in from Ai’s fans across the world when the fine was announced. Eventually an online loan campaign was initiated on 4 November 2011, and close to 9 million RMB was collected within ten days, from 30,000 contributions. Notes were folded into paper planes and thrown over the studio walls, and donations were made in symbolic amounts such as 8964 (4 June 1989, Tiananmen Massacre) or 512 (12 May 2008, Sichuan earthquake). To thank creditors and acknowledge the contributions as loans, Ai designed and issued loan receipts to all who participated in the campaign.[95] Funds raised from the campaign were used as collateral, required by law for an appeal on the tax case. Lawyers acting for Ai submitted an appeal against the fine in January 2012; the Chinese government subsequently agreed to conduct a review.[96]

In June 2012, the court heard the tax appeal case. Ai’s wife, Lu Qing, the legal representative of the design company, attended the hearing. Lu was accompanied by several lawyers and an accountant, but the witnesses they had requested to testify, including Ai, were prevented from attending a court hearing.[97] Ai asserts that the entire matter including the 81 days he spent in jail in 2011 is intended to suppress his provocations. Ai said he had no illusions as to how the case would turn out, as he believes the court will protect the government’s own interests. On 20 June, hundreds of Ai’s supporters gathered outside the Chaoyang District Court in Beijing despite a small army of police officers, some of whom videotaped the crowd and led several people away.[98] On 20 July, Ai’s tax appeal was rejected in court.[99][100] The same day Ai’s studio released “The Fake Case” which tracks the status and history of this case including a timeline and the release of official documents.[101] On 27 September, the court upheld the 2.4million tax evasion fine.[102] Ai had previously deposited 1.33million in a government-controlled account in order to appeal. Ai said he will not pay the remainder because he does not recognize the charge.[103]

In October 2012, authorities revoked the license of Beijing Fake Cultural Development Ltd for failing to re-register, an annual requirement by the administration. The company was not able to complete this procedure as its materials and stamps were confiscated by the government.[104]

On 26 April 2014, Ai’s name was removed from a group show taking place at the Shanghai Power Station of Art. The exhibition was held to celebrate the fifteenth anniversary of the art prize created by Uli Sigg in 1998, with the purpose of promoting and developing Chinese contemporary art. Ai won the Lifetime Contribution Award in 2008 and was part of the jury during the first three editions of the prize.[105] He was then invited to take part in the group show together with the other selected Chinese artists. Shortly before the exhibition’s opening, some museum workers removed his name from the list of winners and jury members painted on a wall. Also, Ai’s works Sunflower Seeds and Stools were removed from the show and kept in a museum office (see photo on Ai Weiwei’s Instagram).[106] Sigg declared that it was not his decision and that it was a decision of the Power Station of Art and the Shanghai Municipal Bureau of Culture.[105]

In May 2014, the Ullens Center for Contemporary Art, a non-profit art center situated in the 798 art district of Beijing, held a retrospective exhibition in honor of the late curator and scholar, Hans Van Dijk. Ai, a good friend of Hans and a fellow co-founder of the China Art Archives and Warehouse (CAAW), participated in the exhibition with three artworks.[107] On the day of the opening, Ai realized his name was omitted from both Chinese and English versions of the exhibition’s press release. Ai’s assistants went to the art center and removed his works.[108] It is Ai’s belief that, in omitting his name, the museum altered the historical record of van Dijk’s work with him. Ai started his own research about what actually happened, and between 23 and 25 May he interviewed the UCCA’s director, Philip Tinari, the guest curator of the exhibition, Marianne Brouwer, and the UCCA chief, Xue Mei.[107] He published the transcripts of the interviews on Instagram.[109][110][111][112][113][114][115][116][117] In one of the interviews, the CEO of the UCCA, Xue Mei, admitted that, due to the sensitive time of the exhibition, Ai’s name was taken out of the press releases on the day of the opening and it was supposed to be restored afterwards. This was to avoid problems with the Chinese authorities, who threatened to arrest her.[107]

Beijing video works

From 2003 to 2005, Ai Weiwei recorded the results of Beijings developing urban infrastructure and its social conditions.

2003, Video, 150 hours

Beginning under the Dabeiyao highway interchange, the vehicle from which Beijing 2003 was shot traveled every road within the Fourth Ring Road of Beijing and documented the road conditions. Approximately 2400 kilometers and 150 hours of footage later, it ended where it began under the Dabeiyao highway interchange. The documentation of these winding alleyways of the city center now largely torn down for redevelopment preserved a visual record of the city that is free of aesthetic judgment.

2004, Video, 10h 13m

Moving from east to west, Changan Boulevard traverses Beijings most iconic avenue. Along the boulevards 45-kilometer length, it recorded the changing densities of its far-flung suburbs, central business districts, and political core. At each 50-meter increment, the artist records a single frame for one minute. The work reveals the rhythm of Beijing as a capital city, its social structure, cityscape, socialist-planned economy, capitalist market, political power center, commercial buildings, and industrial units as pieces of a multi-layered urban collage.

2005, Video, 1h 6m

2005 Video, 1h 50m

Beijing: The Second Ring and Beijing: The Third Ring capture two opposite views of traffic flow on every bridge of each Ring Road, the innermost arterial highways of Beijing. The artist records a single frame for one minute for each view on the bridge. Beijing: The Second Ring was entirely shot on cloudy days, while the segments for Beijing: The Third Ring were entirely shot on sunny days. The films document the historic aspects and modern development of a city with a population of nearly 11 million people.

2007, video, 2h 32m[118]

This video is about Ai Weiwei’s project Fairytale for Europes most innovative five-year art event Documenta 12 in Kassel, Germany in 2007: Ai Weiwei invited 1001 Chinese citizens of different ages and from various backgrounds to Germany to experience their own fairytale for 28 days. The 152 minutes film documents the whole process beginning with project preparations, over the challenge that the participants had to face until the actual travel to Germany, as well as the artists ideas behind the work. This is a work I emotionally relate to. It grows and it surprised me Ai Weiwei in Fairytale.

2008, video, 1h 18m[119]

On 15 December 2008, a citizens investigation began with the goal of seeking an explanation for the casualties of the Sichuan earthquake that happened on 12 May 2008. The investigation covered 14 counties and 74 townships within the disaster zone, and studied the conditions of 153 schools that were affected by the earthquake. By gathering and confirming comprehensive details about the students, such as their age, region, school, and grade, the group managed to affirm that there were 5,192 students who perished in the disaster. Among a hundred volunteers, 38 of them participated in fieldwork, with 25 of them being controlled by the Sichuan police for a total of 45 times. This documentary is a structural element of the citizens investigation.

2009, looped video, 1h 27m[120]

At 14:28 on 12 May 2008, an 8.0-magnitude earthquake happened in Sichuan, China. Over 5,000 students in primary and secondary schools perished in the earthquake, yet their names went unannounced. In reaction to the governments lack of transparency, a citizens investigation was initiated to find out their names and details about their schools and families. As of 2 September 2009, there were 4,851 confirmed. This video is a tribute to these perished students and a memorial for innocent lives lost.

2009, video, 48m[121]

This video documents the story of Chinese citizen Feng Zhenghu and his struggles to return home. The Shanghai authorities rejected Feng Zhenghu, originated from Wenzhou, Jiejiang, China, from returning to the country for a total of eight times in 2009. On 4 November 2009, Feng Zhenghu attempted to return home for the ninth time but the police from Shanghai used violence and kidnapped him to board a flight to Japan. Feng refused to enter Japan and decided to live in the Immigration Hall at Terminal 1 of the Narita Airport in Tokyo, as an act of protest. He relied on food gifts from tourists for sustenance and lived at a passageway in the Narita Airport for 92 days. He posted updates over Twitter, they attracted much concern and led to wide media coverage from Chinese netizens and international communities. On 31 January, Feng announced an end to his protest at the Narita Airport. On 12 February, Feng was allowed entry to China, where he reunited with his family at home in Shanghai. Ai Weiwei and his assistant Gao Yuan, went from Beijing to interview Feng Zhenghu three times at the Narita Airport of Japan on 16 November 20 November 2009 and 31 January 2010, and documented his life at the airport passageway and the entire process of his return to China. No country should refuse entry to its own citizens.

2009, video, 1h 19m[122]

Ai Weiwei studio production Laoma Tihua is a documentary of an incident during Tan Zuorens trial on 12 August 2009. Tan Zuoren was charged with inciting subversion of state power. Chengdu police detained witnessed during the trial of the civil rights advocate, which is an obstruction of justice and violence. Tan Zuoren was charged as a result of his research and questioning regarding the 5.12 Wenchuan students casualties and the corruption resulting poor building construction. Tan Zuoren was sentenced five years to prison.

2010, video, 3h[123]

In June 2008, Yang Jia carried a knife, a hammer, a gas mask, pepper spray, gloves and Molotov cocktails to the Zhabei Public Security Branch Bureau and killed six police officers, injuring another police officer and a guard. He was arrested on the scene, and was subsequently charged with intentional homicide. In the following six months, while Yang Jia was detained and trials were held, his mother has mysteriously disappeared. This video is a documentary that traces the reasons and motivations behind the tragedy and investigates into a trial process filled with shady cover-ups and questionable decisions. The film provides a glimpse into the realities of a government-controlled judicial system and its impact on the citizens lives.

2010, video, 2h 6m[124]

The future dictionary definition of crackdown will be: First cover ones head up firmly, and then beat him or her up violently. @aiww In the summer of 2010, the Chinese government began a crackdown on dissent, and Hua Hao Yue Yuan documents the stories of Liu Dejun and Liu Shasha, whose activism and outspoken attitude led them to violent abuse from the authorities. On separate occasions, they were kidnapped, beaten and thrown into remote locations. The incidents attracted much concern over the Internet, as well as wide speculation and theories about what exactly happened. This documentary presents interviews of the two victims, witnesses and concerned netizens. In which it gathers various perspectives about the two beatings, and brings us closer to the brutal reality of Chinas crackdown on crime.

2010, voice recording, 3h 41m[125]

On 24 April 2010 at 00:51, Ai Weiwei (@aiww) started a Twitter campaign to commemorate students who perished in the earthquake in Sichuan on 12 May 2008. 3,444 friends from the Internet delivered voice recordings, the names of 5,205 perished were recited 12,140 times. Remembrance is an audio work dedicated to the young people who lost their lives in the Sichuan earthquake. It expresses thoughts for the passing of innocent lives and indignation for the cover-ups on truths about sub-standard architecture, which led to the large number of schools that collapsed during the earthquake.

2010, video, 1h 8m[126]

The shooting and editing of this video lasted nearly seven months at the Ai Weiwei studio. It began near the end of 2007 in an interception organized by cat-saving volunteers in Tianjin, and the film locations included Tianjin, Shanghai, Rugao of Jiangsu, Chaoshan of Guangzhou, and Hebei Province. The documentary depicts a complete picture of a chain in the cat-trading industry. Since the end of 2009 when the government began soliciting expert opinion for the Animal Protection Act, the focus of public debate has always been on whether one should be eating cats or not, or whether cat-eating is a Chinese tradition or not. There are even people who would go as far as to say that the call to stop eating cat meat is “imposing the will of the minority on the majority”. Yet the “majority” does not understand the complete truth of cat-meat trading chains: cat theft, cat trafficking, killing cats, selling cats, and eating cats, all the various stages of the trade and how they are distributed across the country, in cities such as Beijing, Tianjin, Shanghai, Nanjing, Suzhou, Wuxi, Rugao, Wuhan, Guangzhou, and Hebei. This well-organized, smooth-running industry chain of cat abuse, cat killing and skinning has already existed among ordinary Chinese folks for 20 years, or perhaps even longer. The degree of civilization of a country can be seen from its attitude towards animals.

2011, video, 1h 1m[127]

This documentary is about the construction project curated by Herzog & de Meuron and Ai Weiwei. One hundred architects from 27 countries were chosen to participate and design a 1000 square meter villa to be built in a new community in Inner Mongolia. The 100 villas would be designed to fit a master plan designed by Ai Weiwei. On 25 January 2008, the 100 architects gathered in Ordos for a first site visit. The film Ordos 100 documents the total of three site visits to Ordos, during which time the master plan and design of each villa was completed. Until today, the Ordos 100 project remains unrealized.

2011, video, 54m[128]

As a sequel to Ai Weiweis film Lao Ma Ti Hua, the film So Sorry (named after the artists 2009 exhibition in Munich, Germany) shows the beginnings of the tension between Ai Weiwei and the Chinese Government. In Lao Ma Ti Hua, Ai Weiwei travels to Chengdu, Sichuan to attend the trial of the civil rights advocate Tan Zuoren, as a witness. In So Sorry, you see the investigation led by Ai Weiwei studio to identify the students who died during the Sichuan earthquake as a result of corruption and poor building constructions leading to the confrontation between Ai Weiwei and the Chengdu police. After being beaten by the police, Ai Weiwei traveled to Munich, Germany to prepare his exhibition at the museum Haus der Kunst. The result of his beating led to intense headaches caused by a brain hemorrhage and was treated by emergency surgery. These events mark the beginning of Ai Weiweis struggle and surveillance at the hands of the state police.

2011, video, 2h 22m[129]

This documentary investigates the death of popular Zhaiqiao village leader Qian Yunhui in the fishing village of Yueqing, Zhejiang province. When the local government confiscated marshlands in order to convert them into construction land, the villagers were deprived of the opportunity to cultivate these lands and be fully self-subsistent. Qian Yunhui, unafraid of speaking up for his villagers, travelled to Beijing several times to report this injustice to the central government. In order to silence him, he was detained by local government repeatedly. On 25 December 2010, Qian Yunhui was hit by a truck and died on the scene. News of the incident and photos of the scene quickly spread over the internet. The local government claimed that Qian Yunhui was the victim of an ordinary traffic accident. This film is an investigation conducted by Ai Weiwei studio into the circumstances of the incident and its connection to the land dispute case, mainly based on interviews of family members, villagers and officials. It is an attempt by Ai Weiwei to establish the facts and find out what really happened on 25 December 2010. During shooting and production, Ai Weiwei studio experienced significant obstruction and resistance from local government. The film crew was followed, sometimes physically stopped from shooting certain scenes and there were even attempts to buy off footage. All villagers interviewed for the purposes of this documentary have been interrogated or illegally detained by local government to some extent.

2011, video, 1h 1m[130]

Early in 2008, the district government of Jiading, Shanghai invited Ai Weiwei to build a studio in Malu Township, as a part of the local government’s efforts in developing its cultural assets. By August 2010, the Ai Weiwei Shanghai Studio completed all of its construction work. In October 2010, the Shanghai government declared the Ai Weiwei Shanghai Studio an illegal construction, and was subjected to demolition. On 7 November 2010, when Ai Weiwei was placed under house arrest by public security in Beijing, over 1,000 netizens attended the “River Crab Feast” at the Shanghai Studio. On 11 January 2011, the Shanghai city government forcibly demolished the Ai Weiwei Studio within a day, without any prior notice.

2013, video, 1h 17m[131]

This video tells the story of Liu Ximei, who at her birth in 1985 was given to relatives to be raised because she was born in violation of Chinas strict one-child policy. When she was ten years old, Liu was severely injured while working in the fields and lost large amounts of blood. While undergoing treatment at a local hospital, she was given a blood transfusion that was later revealed to be contaminated with HIV. Following this exposure to the virus, Liu contracted AIDS. According to official statistics, in 2001 there were 850,000 AIDS sufferers in China, many of whom contracted the illness in the 1980s and 1990s as the result of a widespread plasma market operating in rural, impoverished areas and using unsafe collection methods.

2014, video, 2h 8m[132]

Ai Weiweis Appeal 15,220,910.50 opens with Ai Weiweis mother at the Venice Biennial in the summer of 2013 examining Ais large S.A.C.R.E.D. installation portraying his 81-day imprisonment. The documentary goes onto chronologically reconstruct the events that occurred from the time he was arrested at the Beijing airport in April 2011 to his final court appeal in September 2012. The film portrays the day-to-day activity surrounding Ai Weiwei, his family and his associates ranging from consistent visits by the authorities, interviews with reporters, support and donations from fans, and court dates. The Film premiered at the International Film Festival Rotterdam on 23 January 2014.

2015, video, 30m[133]

This documentary on the Fukushima Art Project is about artist Ai Weiweis investigation of the site as well as the project’s installation process. In August 2014, Ai Weiwei was invited as one of the participating artists for the Fukushima Nuclear Zone by the Japanese art coalition ChimPom, as part of the project Dont Follow the Wind . Ai accepted the invitation and sent his assistant Ma Yan to the exclusion zone in Japan to investigate the site. The Fukushima Nuclear Exclusion Zone is thus far located within the 20-kilometer radius of land area of the Fukushima Daiichi Nuclear Power Plant. 25,000 people have already been evacuated from the Exclusion Zone. Both water and electric circuits were cut off. Entrance restriction is expected to be relieved in the next thirty years, or even longer. The art project will also be open to public at that time. The three spots usable as exhibition spaces by the artists are all former residential houses, among which exhibition site one and two were used for working and lodging; and exhibition site three was used as a community entertainment facility with an ostrich farm. Ai brought about two projects, “A Ray of Hope” and “Family Album” after analyzing materials and information generated from the site. In “A Ray of Hope”, a solar photovoltaic system is built on exhibition site one, on the second level of the old warehouse. Integral LED lighting devices are used in the two rooms. The lights would turn on automatically from 7 to 10pm, and from 6 to 8am daily. This lighting system is the only light source in the Exclusion Zone after this project was installed. Photos of Ai and his studio staff at Caochangdi that make up project “Family Album” are displayed on exhibition site two and three, in the seven rooms where locals used to live. The twenty-two selected photos are divided in five categories according to types of event spanning eight years. Among these photos, six of them were taken from the site investigation at the 2008 Sichuan Earthquake; two were taken during the time when he was illegally detained after pleading the Tan Zuoren case in Chengdu, China in August 2009; and three others taken during his surgical treatment for his head injury from being attacked in the head by police officers in Chengdu; five taken of him being followed by the police and his Beijing studio Fake Design under surveillance due to the studio tax case from 2011 to 2012; four are photos of Ai Weiwei and his family from year 2011 to year 2013; and the other two were taken earlier of him in his studio in Caochangdi (One taken in 2005 and the other in 2006).

Ai’s visual art includes sculptural installations, woodworking, video and photography. “Ai Weiwei: According to What,” adapted and expanded by the Hirshhorn Museum and Sculpture Garden from a 2009 exhibition at Tokyo’s Mori Art Museum, was Ai’s first North American museum retrospective.[134] It opened at the Hirshhorn in Washington, D.C. in 2013, and subsequently traveled to the Brooklyn Museum, New York,[135] and two other venues.

More recent works address his investigation into the aftermath of the Sichuan earthquake and responses to the Chinese government’s detention and surveillance of him.[136]

In 2002, he was the curator of the project Jinhua Architecture Park.

In 2006, Ai and HHF Architects designed a private residence in upstate New York.[137] According to the New York Times, the Tsai Residence is divided into four modules and the details are “extraordinarily refined”.[137][138] In 2009, the Chicago Athenaeum Museum of Architecture and Design selected the home for its International Architecture Awards, one of the world’s most prestigious global awards for new architecture, landscape architecture, interiors and urban planning.[139] In 2010, Wallpaper magazine nominated the residence for its Wallpaper Design Awards category: Best New Private House.[140] A detached guesthouse, also designed by Ai and HHF Architects, was completed after the main house and, according to New York Magazine, looks like a “floating boomerang of rusty Cor-Ten steel.”[141]

In 2008, Ai curated the architecture project Ordos 100 in Ordos City, Inner Mongolia. He invited 100 architects from 29 countries to participate in this project.[142]

Ai was commissioned as the artistic consultant for design, collaborating with the Swiss firm Herzog & de Meuron, for the Beijing National Stadium for the 2008 Summer Olympics, also known as the “Bird’s Nest.”[143] Although ignored by the Chinese media, he had voiced his anti-Olympics views.[3] He later distanced himself from the project, saying, “I’ve already forgotten about it. I turn down all the demands to have photographs with it,” saying it is part of a “pretend smile” of bad taste.[144][145] In August 2007, he also accused those choreographing the Olympic opening ceremony, including Steven Spielberg and Zhang Yimou, of failing to live up to their responsibility as artists. Ai said “It’s disgusting. I don’t like anyone who shamelessly abuses their profession, who makes no moral judgment.”[146] In February 2008, Spielberg withdrew from his role as advisor to the 2008 Summer Olympics.[147][148] When asked why he participated in the designing of the Bird’s Nest in the first place, Ai replied “I did it because I love design.”[149]

In summer 2012, Ai teamed again with Herzog & de Meuron on a “would-be archaeological site [as] a game of make-believe and fleeting memory” as the year’s temporary Serpentine Gallery Pavilion in London’s Kensington Gardens.[150][151]

On 24 October 2012, Ai went live with a cover of Gangnam Style,[152] the famous K-pop phenomenon by South Korean rapper PSY, through the posting of a four-minute long parody video on YouTube. The video was an attempt to criticize the Chinese government’s attempt to silence his activism and was quickly blocked by national authorities.

On 22 May 2013, Ai debuted his first single Dumbass over the internet, with a music video shot by cinematographer Christopher Doyle. The video was a reconstruction of Ai’s experience in prison, during his 81-day detention, and dives in and out of the prison’s reality and the guarding soldiers’ fantasies.[153] He later released a second single, Laoma Tihua, on 20 June 2013 along with a video on his experience of state surveillance, with footage compiled from his studio’s documentaries.[154] On 22 June 2013, the two-year anniversary of Ai’s release, he released his first music album The Divine Comedy.[155] Later in August, he released a third music video for the song Chaoyang Park, also included in the album.[156]

Ai is the Artistic Director of China Art Archives & Warehouse (CAAW), which he co-founded in 1997. This contemporary art archive and experimental gallery in Beijing concentrates on experimental art from the People’s Republic of China, initiates and facilitates exhibitions and other forms of introductions inside and outside China.[157] The building which houses it was designed by Ai in 2000.[158]

On 15 March 2010, Ai took part in Digital Activism in China, a discussion hosted by The Paley Media Center in New York with Jack Dorsey (founder of Twitter) and Richard MacManus.[159] Also in 2010 he served as jury member for Future Generation Art Prize, Kiev, Ukraine; contributed design for Comme de Garcons Aoyama Store, Tokyo, Japan; and participated in a talk with Nobel Prize winner Herta Mller at the International Culture festival Litcologne in Cologne, Germany.

In 2011, Ai sat on the jury of an international initiative to find a universal Logo for Human Rights. The winning design, combining the silhouette of a hand with that of a bird, was chosen from more than 15,300 suggestions from over 190 countries. The initiative’s goal was to create an internationally recognized logo to support the global human rights movement.[98] In 2013, after the existence of the PRISM surveillance program was revealed, Ai said “Even though we know governments do all kinds of things I was shocked by the information about the US surveillance operation, Prism. To me, it’s abusively using government powers to interfere in individuals’ privacy. This is an important moment for international society to reconsider and protect individual rights.”[99]

In 2012, Weiwei interviewed a member of the 50 Cent Party, a group of “online commentators” (otherwise known as sockpuppets) covertly hired by the Chinese government to post “comments favourable towards party policies and [intending] to shape public opinion on internet message boards and forums”.[160] Keeping Ai’s source anonymous, the transcript was published by the British magazine New Statesman on 17 October 2012, offering insights on the education, life, methods and tactics used by professional trolls serving pro-government interests.

Ai designed the cover for 17 June 2013 issue of Time magazine. The cover story, by Hannah Beech, is “How China Sees the World”.[161] TIME Magazine called it “the most beautiful cover we’ve ever done in our history.”[162]

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Space Exploration – Scientific American

Posted: July 31, 2016 at 5:52 am

Space

Dips in starlight reveal the architecture of a super Saturn around a distant star

January 1, 2016 Lee Billings

Space

“Monkey King” is first in a line of Chinese space missions focused on scientific discovery

December 17, 2015 Elizabeth Gibney, Celeste Biever and Davide Castelvecchi

The Sciences

Two controversial new studies suggestthe discovery of large objects at the outer reaches of the solar system

December 10, 2015 Lee Billings

Space

Astronauts already skip ahead in time, but the laws of physics seem to forbid going backwardor do they?

December 10, 2015 Tim Folger

The Sciences

New findings reveal a craters vaporous hazes, and hint at the dwarf planets possible origin in the outer solar system

December 9, 2015 Lee Billings

The Sciences

A new breed of giants raises questions about how the biggest galaxies arise

December 8, 2015 Ken Croswell

The Sciences

New study explores how life on one exoplanet could spread to its neighbor

December 7, 2015 David Rothery and The Conversation

The Sciences

Five years after a failed insertion into planet’s orbit, Akatsuki tries again

December 4, 2015 Alexandra Witze and Nature magazine

The Sciences

A newly passed bill sets the stage for the future of the private spaceflight industry, and could have big implications for asteroid mining

December 4, 2015 Jennifer Hackett

The Sciences

Decision throws construction of the Thirty Meter Telescope into question

December 3, 2015 Alexandra Witze and Nature magazine

Space

November 24, 2015 W. Wayt Gibbs

Space

A dozen quasars in the early universe appear to have shut down in just a few years, baffling astronomers

November 23, 2015 Shannon Hall

Space

Findings from NASAs Cassini spacecraft suggests winter in Titan’s southern hemisphere will be even colder than predicted

November 20, 2015 Nola Taylor Redd and SPACE.com

Space

Scientists photograph a gas-giant exoplanet forming around a young star that lies about 450 light-years from Earth

November 19, 2015 Mike Wall and SPACE.com

Space

What we know about alien worldsand whats coming next

November 18, 2015 Alexandra Witze and Nature magazine

Space

The next-generation, gigantic land-based telescopes are under construction, and they utterly dwarf their predecessors

November 17, 2015

The Sciences

The recently discovered small galaxy Leo P contains only about a hundred-thousandth as many stars as the Milky Way, but it’s bucking the small galaxy trend by continuing to make new ones

November 15, 2015 Ken Croswell and Steve Mirsky

Space

Planetary Society co-founder Louis Friedman argues the Red Planet will be humanitys final destination, but our robots could reach the stars

November 13, 2015 Louis Friedman

The Sciences

Rocky world found orbiting nearby red dwarf star, 39 light-years from Earth

November 12, 2015 Calla Cofield and SPACE.com

The Sciences

More than a hundred times as distant from the sun as Earth is, the object could be a pristine remnant from the primordial solar system

November 10, 2015 Alexandra Witze and Nature magazine

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Architectural Design Philosophy – SFIA

Posted: July 18, 2016 at 3:37 pm

Experiencing great architecture is like enjoying the finest of natural environments. It rewards the senses. It sparks imagination and emotions. It inspires. It enhances consciousness. SFIAs mission is to provide that kind of experience in the process of architectural education. Hundreds of architects, artists, and technologists are working on this level. These are the ones we study and learn from at SFIA. These architects work in ways that are called Organic, Evolutionary, Ecological, and even Extropian or Futurist.

Organic Architecture is integrated with environmental and human needs to a degree never seen in conventional buildings or known to most schools of architecture. The depth and impact of this integration is similar to that found in great music and the natural world. The results, at their best, are a synthesis of function and form, poetry and technology, humanity and nature . . . and extraordinarily uplifting to those fortunate enough to experience it.

Evolutionary and Ecological architectures combine Organic integration with natural process, environmental sensitivity, health awareness, and economical simplicity.

Extropian and Futurist architectures suggest that life and human consciousness can be raised to higher plateaus through visionary applications of advanced technology.

Nature Based Architecture is the overall term that describes all of the above. Nature based architecture represents, in a single phrase, the architecture that is emerging from this school, its teachers, and its students.

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What Is Posthumanism? University of Minnesota Press

Posted: June 24, 2016 at 7:28 am

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Beyond humanism and anthropocentrism

Can a new kind of humanitiesposthumanitiesrespond to the redefinition of humanity’s place in the world by both the technological and the biological or “green” continuum in which the “human” is but one life form among many? Exploring this radical repositioning, Cary Wolfe ranges across bioethics, cognitive science, animal ethics, gender, and disability to develop a theoretical and philosophical approach responsive to our changing understanding of ourselves and our world.

What Is Posthumanism? is an original, thoroughly argued, fundamental redefinition and refocusing of posthumanism. Firmly distinguishing posthumanism from discourses of the posthuman or transhumanism, this book will be at the center of discussion for a long time to come.

Donna Haraway, author of When Species Meet

What does it mean to think beyond humanism? Is it possible to craft a mode of philosophy, ethics, and interpretation that rejects the classic humanist divisions of self and other, mind and body, society and nature, human and animal, organic and technological? Can a new kind of humanitiesposthumanitiesrespond to the redefinition of humanitys place in the world by both the technological and the biological or green continuum in which the human is but one life form among many?

Exploring how both critical thought along with cultural practice have reacted to this radical repositioning, Cary Wolfeone of the founding figures in the field of animal studies and posthumanist theoryranges across bioethics, cognitive science, animal ethics, gender, and disability to develop a theoretical and philosophical approach responsive to our changing understanding of ourselves and our world. Then, in performing posthumanist readings of such diverse works as Temple Grandins writings, Wallace Stevenss poetry, Lars von Triers Dancer in the Dark, the architecture of Diller+Scofidio, and David Byrne and Brian Enos My Life in the Bush of Ghosts, he shows how this philosophical sensibility can transform art and culture.

For Wolfe, a vibrant, rigorous posthumanism is vital for addressing questions of ethics and justice, language and trans-species communication, social systems and their inclusions and exclusions, and the intellectual aspirations of interdisciplinarity. In What Is Posthumanism? he carefully distinguishes posthumanism from transhumanism (the biotechnological enhancement of human beings) and narrow definitions of the posthuman as the hoped-for transcendence of materiality. In doing so, Wolfe reveals that it is humanism, not the human in all its embodied and prosthetic complexity, that is left behind in posthumanist thought.

Cary Wolfe holds the Bruce and Elizabeth Dunlevie Chair in English at Rice University. His previous books include Critical Environments: Postmodern Theory and the Pragmatics of the Outside, Observing Complexity: Systems Theory and Postmodernity, and Zoontologies: The Question of the Animal, all published by the University of Minnesota Press.

What Is Posthumanism? is an original, thoroughly argued, fundamental redefinition and refocusing of posthumanism. Firmly distinguishing posthumanism from discourses of the posthuman or transhumanism, this book will be at the center of discussion for a long time to come.

Donna Haraway, author of When Species Meet

Wolfe offers a smart, provocative account of posthumanism as an idea and as a way of thinking that has consequences extending from the way universities are organized to decisions regarding public policy bioethics. Although his writing is complex and demanding, the ethical and ecological urgency with which he frames his readings combines with the wide, diversified scope of his scholarship to make this a work to be reckoned with.

Wolfes book, without a doubt, supplies important insights.

Wolfe has created an incredibly useful primer on posthumanist theory. For anyone attempting to engage in academic work relating to these theories, this book is a highly recommended starting point.

Big Muddy: A Journal of the Mississippi River Valley

It is one of those books that sucks you in almost immediately.

ISLE: Interdisciplinary Studies in Literature and Environment

Readers . . . will find Wolfes analysis of both visual and audio culture to be thought-provoking.

Science Fiction Film and Television

It is a profound, thoroughly researched study with far-reaching consequences for public policy, bioethics, education, and the arts.

Science, Culture, Integrated Yoga

What Is Posthumanism? is an intelligent, extensively argued and challenging work.

Wolfes work shifts the tired terms of the debate in new and needed directions, offering strength and strategies to all those for whom simplistic, technophilic accounts of the posthuman condition are a smooth road to nowhere different.

Electronic Book Review

Tremendous intellectual, scholarly, and artistic breadth.

As a blueprint for where a posthumanist approach could take cultural theory, his book is conceptually invaluable.

Wolfes posthumanism is brilliant in the way it allows us to realize that each of the
se species might have different forms of perception, different ways of being in the world, and that those differences are actually analogous with otherness among human beings.

Wolfe deserves credit for a rich set of discussions that, taken together, bring out the interest of the intellectual trend that he calls posthumanism.

UMP blog: Discovering the HUMAN

3/24/2010 Part of the unfortunate fallout of the conceptual apparatus of humanism is that it gives us an overly simple picturea fantasy, reallyof what the human is. Consider, for example, the rise of what is often called transhumanism, often taken to be a defining discourse of posthumanism (as in Ray Kurzweils work on the singularitythe historical moment at which engineering developments such as nanotechnology enable us to transcend our physical and biological limitations as embodied beings, ushering in a new phase of evolution). As many of its proponents freely admit, the philosophical ideals of transhumanism are quite identifiably humanistnot only in their dream of transcending the life of the body and our animal origins but also in their investment in the ideals of human perfectibility, rationality, autonomy, and agency. Read more …

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Retreat (survivalism) – Wikipedia, the free encyclopedia

Posted: June 17, 2016 at 4:52 am

A retreat is a place of refuge for those in the survivalist subculture or movement. A retreat is also sometimes called a bug-out location (BOL). Survivalist retreats are intended to be self-sufficient and easily defended, and are generally located in sparsely populated rural areas.

While fallout shelters have been advocated since the 1950s, dedicated self-sufficient survivalist retreats have been advocated only since the mid-1970s. The survival retreat concept has been touted by a number of influential survivalist writers including Ragnar Benson, Barton Biggs, Bruce D. Clayton, Jeff Cooper, Cresson Kearny, James Wesley Rawles, Howard Ruff, Kurt Saxon, Joel Skousen, Don Stephens, Mel Tappan, and Nancy Tappan.[citation needed]

With the increasing inflation of the 1960s, the impending US monetary devaluation, the continuing concern with possible nuclear exchanges between the US and the Soviet Union, and the increasing vulnerability of urban centers to supply shortages and other systems failures, a number of primarily conservative and libertarian thinkers began suggesting that individual preparations would be wise. Harry Browne began offering seminars in 1967 on how to survive a monetary collapse. He worked with Don Stephens, an architect, survival bookseller, and author, who provided input on how to build and equip a remote survival retreat. He provided a copy of his original Retreater’s Bibliography (1967) for each seminar participant.

Articles on the subject appeared in such small-distribution libertarian publications as The Innovator and Atlantis Quarterly. It was also from this period that Robert D. Kephart began publishing Inflation Survival Letter[1] (later renamed Personal Finance). The newsletter included a continuing section on personal preparedness by Stephens for several years. It promoted expensive seminars around the US on the same cautionary topics. Stephens participated, along with James McKeever and other defensive investing, hard currency advocates.

In 1975, Kurt Saxon began publishing a newsletter called The Survivor, which advocated moving to lightly populated regions to “lie low” during a socio-economic collapse, and setting up fortified enclaves for defense against what he termed “killer caravans”[2][3] of looters from urban areas.

In 1976, Don Stephens popularized the term “retreater” and advocated relocating to a rural retreat when society breaks down.

Writers such as Howard Ruff warned about socio-economic collapse and recommended moving to lightly populated farming regions, most notably in his 1979 book How to Prosper During the Coming Bad Years, a best-seller in 1979.

For a time in the 1970s, the terms “survivalist” and “retreater” were used interchangeably. The term “retreater” eventually fell out of favor.[4]

One of the most important newsletters on survivalism and survivalist retreats in the 1970s was the Personal Survival (“P.S.”) Letter (circa 1977-1982) published by Mel Tappan, who also authored the books Survival Guns and Tappan on Survival. The newsletter included columns from Tappan himself, as well from Jeff Cooper, Al J. Venter, Bill Pier, Bruce D. Clayton, Rick Fines, Nancy Mack Tappan, J.B. Wood, Dr. Carl Kirsch, Charles Avery, Karl Hess, Eugene A. Barron, Janet Groene, Dean Ing, Bob Taylor, Reginald Bretnor, C.G. Cobb, and several other writers, some under pen names. The majority of this newsletter revolved around selecting, constructing and logistically equipping survival retreats.[5] Following Tappan’s death in 1980, Karl Hess took over publishing the newsletter, eventually renaming it Survival Tomorrow.

Survivalist retreat books of the 1980s were typified by the 1980 book Life After Doomsday[6] by Bruce D. Clayton, advocating survival retreats in locales that would minimize fallout, as well as specially constructing blast shelters and/or fallout shelters that would provide protection in the event of a nuclear war.

Several books published in the 1990s offered advice on survival retreats and relocation. Some influential in survivalist circles are Survival Retreat: A Total Plan For Retreat Defense by Ragnar Benson, Strategic RelocationNorth American Guide to Safe Places by Joel Skousen, and The Secure Home, (also by Skousen).

In recent years, advocacy of survivalist retreats has had a strong resurgence after the terrorist attacks on the World Trade Center in New York in 2001, the 2002 attacks and 2005 attacks in Bali, the 2004 Madrid train bombings in Spain, and the 2005 public transportation bombings in London.[citation needed]

Several books published since 2000 advocate survival retreats and relocation. Some that have been particularly influential in survivalist circles are How to Implement a High Security Shelter in the Home by Joel Skousen, Rawles on Retreats and Relocation by James Wesley Rawles, and Life After Terrorism: What You Need to Know to Survive in Today’s World by Bruce D. Clayton.[7]

Online survival websites, forums, and blogs (such as SurvivalBlog) discuss the best locales for survival retreats, how to build, fortify, and equip them, and how to form survivalist retreat groups.[8]

Economic troubles emerging from the credit collapse triggered by the 2007 US subprime mortgage crisis have prompted a wider cross-section of the populace to modify their homes as well as establish dedicated survival retreats.[9] James Wesley Rawles, the editor of SurvivalBlog was quoted by the New York Times in April 2008 that “interest in the survivalist movement ‘is experiencing its largest growth since the late 1970s’. He also stated that his blog’s conservative core readership has been supplemented with “an increasing number of stridently green and left-of-center readers.”[9]

Mel Tappan was quoted in 1981 by then AP correspondent Peter Arnett that: “The concept most fundamental to long term disaster preparedness, in retreating, is having a safe place to go to avoid the concentrated violence destined to erupt in the cities.” [10]

Common retreat locale selection parameters include light population density, plentiful water, arable land, good solar exposure for gardening and photovoltaics, situation above any flood plains, and a diverse and healthy local economy.[11] Fearing rioting, looting and other unrest, many survivalists advocate selecting retreat locales that are more than one tank of gasoline away from any major metropolitan region. Properties that are not in “channelized areas” or on anticipated “refugee lines of drift” are also touted.[12]

One of the key goals of retreats is to be self-sufficient for the duration of societal collapse. To that end, plentiful water and arable soil are paramount considerations. Beyond that, a priority is situation on isolated, defensible terrain. Typically, retreats do not want their habitations or structures jeopardized by being within line of sight of any major highway.

Because of its low population density and diverse economy, James Wesley Rawles [13] and Joel Skousen [14] both recommend the Intermountain West region of the United States as a preferred region for relocation and setting up retreats. Although it has higher population density, Mel Tappan recommended southwestern Oregon, where he lived,[15] primarily because it is not downwind of any envisioned nuclear targets in the United States.

Mel Tappan was disappointed by the demographics of southwestern Oregon after the survivalist influx of the late 1970s. “Too many doctors and lawyers” relocated to Oregon, and “not enough plumbers, electricians, or carpent
ers.”[15]

While some survivalists recommend living at a rural retreat year-round,[16] most survivalists cannot afford to do so. Therefore, they rely on keeping a well-stocked retreat, and plan to go there “at the 11th hour”, as necessary. They keep a bug-out bag handy, and may have a dedicated bug-out vehicle (BOV). This is a vehicle that the owner keeps prepared in the event of the need for an emergency evacuation. Typically a BOV is equipped with a variation on the bug-out bag that includes additional automotive supplies, clothing, food and water. Survivalists tend to favor four wheel drive trucks and SUVs due to their greater off-road abilities. In the event of a nuclear catastrophe, survivalists may opt into maintaining an older vehicle since it most likely lacks critical electronic components that would otherwise be damaged by the electromagnetic pulse that accompanies a nuclear explosion.

Most survivalist retreats are created by individuals and their families, but larger “group retreats” or “covenant communities” are formed along the lines of an intentional community.

Jeff Cooper popularized the concept of hardening retreats against small arms fire. In an article titled “Notes on Tactical Residential Architecture” in Issue #30 of P.S. Letter (April, 1982), Cooper suggested using the “Vauban Principle”, whereby projecting bastion corners would prevent miscreants from being able to approach a retreat’s exterior walls in any blind spots. Corners with this simplified implementation of a Vauban Star are now called “Cooper Corners” by James Wesley Rawles, in honor of Jeff Cooper.[17] Depending on the size of the group needing shelter, design elements of traditional European castle architecture, as well as Chinese Fujian Tulou and Mexican walled courtyard houses have been suggested for survival retreats.

In both his book Rawles on Retreats and Relocation and in his survivalist novel, Patriots: A Novel of Survival in the Coming Collapse, Rawles describes in great detail retreat groups “upgrading” brick or other masonry houses with steel reinforced window shutters and doors, excavating anti-vehicular ditches, installing warded gate locks, constructing concertina wire obstacles and fougasses, and setting up listening post/observation posts (LP/OPs.) Rawles is a proponent of including a mantrap foyer at survival retreats, an architectural element that he calls a “crushroom”.[18]

Bruce D. Clayton and Joel Skousen have both written extensively on integrating fallout shelters into retreat homes, but they put less emphasis on ballistic protection and exterior perimeter security than Cooper and Rawles.

Anticipating long periods of time without commerce in the future, as well as observing documented history, retreat groups typically place a strong emphasis on logistics. They amass stockpiles of supplies for their own use, for charity, and for barter. Frequently cited key logistics for a retreat include long term storage food, common caliber ammunition, medical supplies, tools, gardening seed, and fuel. In an article titled “Ballistic Wampum” in Issue #6 of P.S. Letter (1979) Jeff Cooper wrote about stockpiling ammunition far in excess of his own needs, keeping the extra available to use for bartering.

In their books, Joel Skousen, Mel Tappan and Howard Ruff all emphasize the need to have a one-year supply of storage food.

Mainstream economist and financial adviser Barton Biggs is a proponent of well-stocked retreats. In his 2008 book Wealth, War and Wisdom, Biggs has a gloomy outlook for the economic future, and suggests that investors take survivalist measures. In the book, Biggs recommends that his readers should assume the possibility of a breakdown of the civilized infrastructure. He goes so far as to recommend setting up survival retreats: Your safe haven must be self-sufficient and capable of growing some kind of food, Mr. Biggs writes. It should be well-stocked with seed, fertilizer, canned food, wine, medicine, clothes, etc. Think Swiss Family Robinson. Even in America and Europe there could be moments of riot and rebellion when law and order temporarily breaks down.[9]

Survivalist retreats, both formal and informal exist worldwide, most visibly in Australia,[19] Belgium, Canada,[20] France,[21] Germany[22] (often organized under the guise of “adventuresport” clubs),[23] New Zealand,[24] Norway,[25] Russia,[26] Sweden,[27] the United Kingdom[28] and the United States.[9]

Construction of government-built retreats and underground sheltersroughly analogous to survivalist retreatshas been done extensively since the advent of the Cold War, especially of public nuclear fallout shelters in many nations. The United States government has created Continuity of Government (COG) shelters built by the Department of Defense and Federal Emergency Management Agency (“FEMA”). These include the massive shelter built under the Greenbrier hotel (aka Project Greek Island), military facilities like Cheyenne Mountain Complex, and the Raven Rock Mountain Complex and Mount Weather sites. Other nations’ facilities include the Swiss redoubt fortress system and its dual use facilities like the Sonnenberg Tunnel and Norway’s Sentralanlegget bunker in Buskerud County.

Robert A. Heinlein featured survivalist retreats in some of his science fiction. Farnham’s Freehold (1964) begins as a story of a small group in a survivalist retreat during a nuclear war. Heinlein also wrote essays such as How to be a Survivor[29] which provide advice on preparing for and surviving a nuclear war, including stocking a fallout shelter and retreat.

Malevil by French writer Robert Merle (1972) describes refurbishing a medieval castle and its use as a survivalist stronghold in the aftermath of a full-scale nuclear war. The novel was adapted into a 1981 film directed by Christian de Chalonge and starring Michel Serrault, Jacques Dutronc, Jacques Villeret and Jean-Louis Trintignant.[30]

Lucifer’s Hammer by Jerry Pournelle and Larry Niven (1977) is about a cataclysmic comet hitting the Earth, and a group of people struggling to survive the aftermath.

Patriots: A Novel of Survival in the Coming Collapse by James Wesley Rawles (2009) describes how the lead characters establish a self-sufficient survival retreat in north-central Idaho.

Jericho (2006) is a TV series that portrays a small town in Kansas after a series of nuclear explosions across the United States. In the series, the character Robert Hawkins uses his prior planning and survival skills in preparation of the attacks. Although it is not fortified, the town effectively becomes a large scale retreat, for its residents.

The text of some books discussing survivalist retreats can be found online:

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Retreat (survivalism) – Wikipedia, the free encyclopedia

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10 Utopian Intentional Communities with Distinct Values

Posted: June 12, 2016 at 12:41 am

Stephanie Rogers 4 years ago

From tree house villages in Costa Rica to yoga communes in Hawaii, these 10 intentional communities are havens of peace, creativity and sustainability.

Imagine waking up to the sound of bells from a temple to share in a morning yoga ritual overlooking the mountains of Peru, or the glittering Pacific Ocean in Hawaii. Picking fresh vegetables from your neighborhood garden to cook in a community-wide meal in a spacious, shared kitchen. Building your own non-toxic, mortgage-free cob house in a low-impact neighborhood of like-minded nature lovers. Stepping out of your very own treehouse to gaze at a network of aerial walkways that look like something out of a sci-fi movie. These 10 intentional communities, from utopian eco-villages to cute historic houses in urban Los Angeles, bring people together with common goals of harmonic living, artistic exploration and sustainability.

Polestar Yoga Community, Big Island, Hawaii

What could be more relaxing than a yoga community in Hawaii? Polestar offers an energizing lifestyle of daily yoga and meditation, karmic yoga or service projects, and outdoor adventure opportunities. Though it bills itself as a spiritual community, people of all faiths are welcome at this cooperative living retreat which is home to full-time residents and also open to visitors and apprentices. Awakened each morning by the sound of music from the temple, a shrine dedicated to the teachings of Paramhansa Yogananda, guests enjoy daily routines involving organic food grown on site, volunteer service, art and lots of community involvement.

Eco Truly Park, Peru

It looks like something out of a fairy tale: adorable little cone-shaped buildings topped with colorfully painted spires, dotting the hillside on the Pacific coast of Peru. This ecological and artistic community, an hour north of Lima, was founded on principles of non-violence, simple living and harmony with nature. Both the architecture and the values of the community are inspired by traditional Indian teachings and lifestyles. Eco Truly Park has a goal of being fully self-sustainable, and currently boasts a large organic garden. Open to volunteers, the community offers workshops in yoga, art and Vedic philosophy.

Synchronicity Artist Commune, Los Angeles, California

Embodying the laid-back lifestyle of sunny Southern California, Synchronicity is a relaxed and welcoming intentional living community in the historic West Adams District of Los Angeles. Though its small nowhere near the size of the rest of the communities on this list Synchronicity is a great example of the thousands of similar shared households around the United States. Synchronicity has eleven residents and focuses mostly on artistic actions and holding monthly artistic salons that are open to the public.

Earthhaven Ecovillage, Asheville, North Carolina

Located in the mountains of Western North Carolina, Earthaven is just one of many similar intentional communities focusing on sustainable living. Youll find virtually every type of natural building here, including earthships, cob houses and rustic cabins, with construction methods that eliminate toxic materials, logged timber and mortgages. Set on 320 lush acres 40 minutes southwest of Asheville, Earthaven frequently holds natural building workshops and welcomes the public to learn about permaculture, organic gardening and other sustainable topics. They offer camping and visitor accommodations as well as live-work arrangements.

Milagro Cohousing, Tucson, Arizona

Twelve minutes from downtown Tucson, Arizona, Milagro is a co-housing community with 28 passive-solar, energy-efficient adobe homes on 43 acres. Set against the Tucson mountains, Milagro is simply a community of people who want to live a green lifestyle, surrounded by like-minded neighbors. Each resident has access to 35 acres of undeveloped open space, as well as the 3,600-square-foot Common House, which has meeting and dining space, a library, a playroom and storage space. Gardens, workshops and a solar-heated swimming pool make it even more enticing.

Finca Bellavista Treehouse Community, Costa Rica

If youve ever watched Star Wars and wished that you could live with the Ewoks in their magical tree house community, take heed: such a thing actually exists. And its in Costa Rica. Finca Bellavista is a network of rustic, hand-built tree houses in the mountainous South Pacific coastal region of this Central American nation, surrounded by a jungle that is brimming with life. The off-grid, carbon-neutral tree houses are connected by aerial walkways and include a central community center with a dining area, barbecue and lounge. Gardens, ziplines and hiking trails make it even more of a tropical paradise. Prospective community members can design and build their own tree houses. Additionally, some of the tree house owners rent out their homes, and there are visitor accommodations available.

Tamera Peace Research Village, Portugal

Aiming to be a totally self-sufficient community, the Tamera Peace Research Village is in the Alentejo region of southwestern Portugal and is home to 250 coworkers and students who study how humans can live peacefully in sustainable communities, in harmony with nature. It includes a non-profit peace foundation, a SolarVillage test site, a permaculture project with an edible landscape, and a sanctuary for horses.

Dancing Rabbit Eco Village, Missouri

Another showcase of the beauty of natural building techniques, the Dancing Rabbit Eco Village is a sustainable community located near Rutledge, Missouri advocating low-impact living and dedication to social change. Everything from members diets to the way they use water is dictated by a commitment to living lightly on the earth. The village is on 280 acres including six ponds, a small creek and 40 acres of woodland, plus 30 acres where they have planted over 12,000 trees as part of a restoration program.

EcoVillage at Ithaca, New York

What would the ideal sustainable community look like? The EcoVillage at Ithaca is one example that is already thriving in the Finger Lakes region of upstate New York. It includes three co-housing neighborhoods called Frog, Song and Tree as well as an organic CSA vegetable farm, community gardens and over 100 acres of protected green space. The houses are all energy-efficient and share facilities like a common house, wood shop, metal shop, bike shed, playgrounds and centralized compost bins.

Conceptual Community of Tiny Houses

Its not yet a reality, but tiny house enthusiasts have a dream: idyllic neighborhoods where people who have committed to living in very small spaces can get together and share resources and camaraderie. Tiny house communities are hard to come by because of various city and county ordinances, which favor large houses and conventional utilities. At TinyHouseCommunity.com, people who live in tiny houses or want to build their own some day get together to talk about making these villages happen. There are two tiny house communities currently in planning phases, in Washington D.C. and Texas.

Top photo: Dancing Rabbit Eco Village

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10 Utopian Intentional Communities with Distinct Values

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Cystic fibrosis – Wikipedia, the free encyclopedia

Posted: June 10, 2016 at 12:44 pm

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs but also the pancreas, liver, kidneys, and intestine.[1][2] Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in males, among others. Different people may have different degrees of symptoms.[1]

CF is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein.[1] Those with a single working copy are carriers and otherwise mostly normal.[3] CFTR is involved in production of sweat, digestive fluids, and mucus.[4] When CFTR is not functional, secretions which are usually thin instead become thick.[5] The condition is diagnosed by a sweat test and genetic testing.[1] Screening of infants at birth takes place in some areas of the world.[1]

There is no cure for cystic fibrosis.[3] Lung infections are treated with antibiotics which may be given intravenously, inhaled, or by mouth. Sometimes the antibiotic azithromycin is used long term. Inhaled hypertonic saline and salbutamol may also be useful. Lung transplantation may be an option if lung function continues to worsen. Pancreatic enzyme replacement and fat-soluble vitamin supplementation are important, especially in the young. While not well supported by evidence, many people use airway clearance techniques such as chest physiotherapy.[1] The average life expectancy is between 42 and 50 years in the developed world.[6][7] Lung problems are responsible for death in 80% of people with cystic fibrosis.[1]

CF is most common among people of Northern European ancestry and affects about one out of every 3,000 newborns.[1] About one in 25 people are carriers.[3] It is least common in Africans and Asians.[1] It was first recognized as a specific disease by Dorothy Andersen in 1938, with descriptions that fit the condition occurring at least as far back as 1595.[2] The name cystic fibrosis refers to the characteristic fibrosis and cysts that form within the pancreas.[2][8]

The main signs and symptoms of cystic fibrosis are salty-tasting skin,[9] poor growth, and poor weight gain despite normal food intake,[10] accumulation of thick, sticky mucus,[11] frequent chest infections, and coughing or shortness of breath.[12] Males can be infertile due to congenital absence of the vas deferens.[13] Symptoms often appear in infancy and childhood, such as bowel obstruction due to meconium ileus in newborn babies.[14] As the children grow, they exercise to release mucus in the alveoli.[15]Ciliated epithelial cells in the person have a mutated protein that leads to abnormally viscous mucus production.[11] The poor growth in children typically presents as an inability to gain weight or height at the same rate as their peers and is occasionally not diagnosed until investigation is initiated for poor growth. The causes of growth failure are multifactorial and include chronic lung infection, poor absorption of nutrients through the gastrointestinal tract, and increased metabolic demand due to chronic illness.[10]

In rare cases, cystic fibrosis can manifest itself as a coagulation disorder. Vitamin K is normally absorbed from breast milk, formula, and later, solid foods. This absorption is impaired in some cystic fibrosis patients. Young children are especially sensitive to vitamin K malabsorptive disorders because only a very small amount of vitamin K crosses the placenta, leaving the child with very low reserves and limited ability to absorb vitamin K from dietary sources after birth. Because factors II, VII, IX, and X (clotting factors) are vitamin Kdependent, low levels of vitamin K can result in coagulation problems. Consequently, when a child presents with unexplained bruising, a coagulation evaluation may be warranted to determine whether there is an underlying disease.[16]

Lung disease results from clogging of the airways due to mucus build-up, decreased mucociliary clearance, and resulting inflammation.[17][18] Inflammation and infection cause injury and structural changes to the lungs, leading to a variety of symptoms. In the early stages, incessant coughing, copious phlegm production, and decreased ability to exercise are common. Many of these symptoms occur when bacteria that normally inhabit the thick mucus grow out of control and cause pneumonia. In later stages, changes in the architecture of the lung, such as pathology in the major airways (bronchiectasis), further exacerbate difficulties in breathing. Other signs include coughing up blood (hemoptysis), high blood pressure in the lung (pulmonary hypertension), heart failure, difficulties getting enough oxygen to the body (hypoxia), and respiratory failure requiring support with breathing masks, such as bilevel positive airway pressure machines or ventilators.[19]Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa are the three most common organisms causing lung infections in CF patients.[18] In addition to typical bacterial infections, people with CF more commonly develop other types of lung disease. Among these is allergic bronchopulmonary aspergillosis, in which the body’s response to the common fungus Aspergillus fumigatus causes worsening of breathing problems. Another is infection with Mycobacterium avium complex (MAC), a group of bacteria related to tuberculosis, which can cause a lot of lung damage and does not respond to common antibiotics.[20]

Mucus in the paranasal sinuses is equally thick and may also cause blockage of the sinus passages, leading to infection. This may cause facial pain, fever, nasal drainage, and headaches. Individuals with CF may develop overgrowth of the nasal tissue (nasal polyps) due to inflammation from chronic sinus infections.[21] Recurrent sinonasal polyps can occur in as many as 10% to 25% of CF patients.[18] These polyps can block the nasal passages and increase breathing difficulties.[22][23]

Cardiorespiratory complications are the most common cause of death (~80%) in patients at most CF centers in the United States.[18]

Prior to prenatal and newborn screening, cystic fibrosis was often diagnosed when a newborn infant failed to pass feces (meconium). Meconium may completely block the intestines and cause serious illness. This condition, called meconium ileus, occurs in 510%[18][24] of newborns with CF. In addition, protrusion of internal rectal membranes (rectal prolapse) is more common, occurring in as many as 10% of children with CF,[18] and it is caused by increased fecal volume, malnutrition, and increased intraabdominal pressure due to coughing.[25]

The thick mucus seen in the lungs has a counterpart in thickened secretions from the pancreas, an organ responsible for providing digestive juices that help break down food. These secretions block the exocrine movement of the digestive enzymes into the duodenum and result in irreversible damage to the pancreas, often with painful inflammation (pancreatitis).[26] The pancreatic ducts are totally plugged in more advanced cases, usually seen in older children or adolescents.[18] This causes atrophy of the exocrine glands and progressive fibrosis.[18]

The lack of digestive enzymes leads to difficulty absorbing nutrients with their subsequent excretion in the feces, a disorder known as malabsorption. Malabsorption leads to malnutrition and poor growth and development because of calorie loss. Resultant hypoproteinemia may be severe enough to cause generalized edema.[18] Individuals with CF also have difficulties absorbing the fat-soluble vitamins A, D, E, and K.

In addition to the pancreas problems, people with cystic fibrosis experience more heartburn, intestinal blockage by intussusception, and constipation.[27] Older individuals with CF may develop distal intestinal obstruction syndrome when thickened feces cause intestinal blockage.[28]

Exocrine pancreatic insufficiency occurs in the majority (85% to 90%) of patients with CF.[18] It is mainly associated with “severe” CFTR mutations, where both alleles are completely nonfunctional (e.g. F508/F508).[18] It occurs in 10% to 15% of patients with one “severe” and one “mild” CFTR mutation where there still is a little CFTR activity, or where there are two “mild” CFTR mutations.[18] In these milder cases, there is still sufficient pancreatic exocrine function so that enzyme supplementation is not required.[18] There are usually no other GI complications in pancreas-sufficient phenotypes, and in general, such individuals usually have excellent growth and development.[18] Despite this, idiopathic chronic pancreatitis can occur in a subset of pancreas-sufficient individuals with CF, and is associated with recurrent abdominal pain and life-threatening complications.[18]

Thickened secretions also may cause liver problems in patients with CF. Bile secreted by the liver to aid in digestion may block the bile ducts, leading to liver damage. Over time, this can lead to scarring and nodularity (cirrhosis). The liver fails to rid the blood of toxins and does not make important proteins, such as those responsible for blood clotting.[29][30] Liver disease is the third most common cause of death associated with CF.[18]

The pancreas contains the islets of Langerhans, which are responsible for making insulin, a hormone that helps regulate blood glucose. Damage of the pancreas can lead to loss of the islet cells, leading to a type of diabetes that is unique to those with the disease.[31] This cystic fibrosis-related diabetes (CFRD) shares characteristics that can be found in type 1 and type 2 diabetics, and is one of the principal nonpulmonary complications of CF.[32]Vitamin D is involved in calcium and phosphate regulation. Poor uptake of vitamin D from the diet because of malabsorption can lead to the bone disease osteoporosis in which weakened bones are more susceptible to fractures.[33] In addition, people with CF often develop clubbing of their fingers and toes due to the effects of chronic illness and low oxygen in their tissues.[34][35]

Infertility affects both men and women. At least 97% of men with cystic fibrosis are infertile, but not sterile and can have children with assisted reproductive techniques.[36] The main cause of infertility in men with cystic fibrosis is congenital absence of the vas deferens (which normally connects the testes to the ejaculatory ducts of the penis), but potentially also by other mechanisms such as causing no sperm, teratospermia, and few sperm with poor motility.[37] Many men found to have congenital absence of the vas deferens during evaluation for infertility have a mild, previously undiagnosed form of CF.[38] Approximately 20% of women with CF have fertility difficulties due to thickened cervical mucus or malnutrition. In severe cases, malnutrition disrupts ovulation and causes a lack of menstruation.[39]

CF is caused by a mutation in the gene cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation, F508, is a deletion ( signifying deletion) of three nucleotides[40] that results in a loss of the amino acid phenylalanine (F) at the 508th position on the protein. This mutation accounts for two-thirds (6670%[18]) of CF cases worldwide and 90% of cases in the United States; however, there are over 1500 other mutations that can produce CF.[41] Although most people have two working copies (alleles) of the CFTR gene, only one is needed to prevent cystic fibrosis. CF develops when neither allele can produce a functional CFTR protein. Thus, CF is considered an autosomal recessive disease.

The CFTR gene, found at the q31.2 locus of chromosome 7, is 230,000 base pairs long, and creates a protein that is 1,480 amino acids long. More specifically the location is between base pair 117,120,016 to 117,308,718 on the long arm of chromosome 7, region 3, band 1, sub-band 2, represented as 7q31.2. Structurally, CFTR is a type of gene known as an ABC gene. The product of this gene (the CFTR) is a chloride ion channel important in creating sweat, digestive juices and mucus. This protein possesses two ATP-hydrolyzing domains, which allows the protein to use energy in the form of ATP. It also contains two domains comprising 6 alpha helices apiece, which allow the protein to cross the cell membrane. A regulatory binding site on the protein allows activation by phosphorylation, mainly by cAMP-dependent protein kinase.[19] The carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZ domain interaction.[42]

In addition, there is increasing evidence that genetic modifiers besides CFTR modulate the frequency and severity of the disease. One example is mannan-binding lectin, which is involved in innate immunity by facilitating phagocytosis of microorganisms. Polymorphisms in one or both mannan-binding lectin alleles that result in lower circulating levels of the protein are associated with a threefold higher risk of end-stage lung disease, as well as an increased burden of chronic bacterial infections.[18]

There are several mutations in the CFTR gene, and different mutations cause different defects in the CFTR protein, sometimes causing a milder or more severe disease. These protein defects are also targets for drugs which can sometimes restore their function. F508-CFTR, which occurs in >90% of patients in the U.S., creates a protein that does not fold normally and is not appropriately transported to the cell membrane, resulting in its degradation. Other mutations result in proteins that are too short (truncated) because production is ended prematurely. Other mutations produce proteins that: do not use energy normally, do not allow chloride, iodide, and thiocyanate to cross the membrane appropriately,[43] degrade at a faster rate than normal. Mutations may also lead to fewer copies of the CFTR protein being produced.[19]

The protein created by this gene is anchored to the outer membrane of cells in the sweat glands, lungs, pancreas, and all other remaining exocrine glands in the body. The protein spans this membrane and acts as a channel connecting the inner part of the cell (cytoplasm) to the surrounding fluid. This channel is primarily responsible for controlling the movement of halogens from inside to outside of the cell; however, in the sweat ducts it facilitates the movement of chloride from the sweat duct into the cytoplasm. When the CFTR protein does not resorb ions in sweat ducts, chloride and thiocyanate[44] released from sweat glands are trapped inside the ducts and pumped to the skin. Additionally hypothiocyanite, OSCN, cannot be produced by the immune defense system.[45][46] Because chloride is negatively charged, this modifies the electrical potential inside and outside the cell that normally causes cations to cross into the cell. Sodium is the most common cation in the extracellular space. The excess chloride within sweat ducts prevents sodium resorption by epithelial sodium channels and the combination of sodium and chloride creates the salt, which is lost in high amounts in the sweat of individuals with CF. This lost salt forms the basis for the sweat test.[19]

Most of the damage in CF is due to blockage of the narrow passages of affected organs with thickened secretions. These blockages lead to remodeling and infection in the lung, damage by accumulated digestive enzymes in the pancreas, blockage of the intestines by thick faeces, etc. There are several theories on how the defects in the protein and cellular function cause the clinical effects. The most current theory suggests that defective ion transport leads to dehydration in the airway epithelia, thickening mucus. In airway epithelial cells, the cilia exist in between the cell’s apical surface and mucus in a layer known as Airway Surface Liquid (ASL). The flow of ions from the cell and into this layer is determined by ion channels like CFTR. CFTR not only allows Chloride ions to be drawn from the cell and into the ASL, but it also regulates another channel called ENac. ENac allows sodium ions to leave the ASL and enter the respiratory epithelium. CFTR normally inhibits this channel, but if the CFTR is defective, then sodium will flow freely from the ASL and into the cell. As water follows sodium, the depth of ASL will be depleted and the cilia will be left in the mucous layer.[47] As cilia cannot effectively move in a thick viscous environment, there is deficient mucociliary clearance and a buildup of mucous, clogging small airways.[48] The accumulation of more viscous, nutrient-rich mucus in the lungs allows bacteria to hide from the body’s immune system, causing repeated respiratory infections. The presence of the same CFTR proteins in pancreatic duct and skin cells are what cause symptoms in these systems.

The lungs of individuals with cystic fibrosis are colonized and infected by bacteria from an early age. These bacteria, which often spread among individuals with CF, thrive in the altered mucus, which collects in the small airways of the lungs. This mucus leads to the formation of bacterial microenvironments known as biofilms that are difficult for immune cells and antibiotics to penetrate. Viscous secretions and persistent respiratory infections repeatedly damage the lung by gradually remodeling the airways, which makes infection even more difficult to eradicate.[49]

Over time, both the types of bacteria and their individual characteristics change in individuals with CF. In the initial stage, common bacteria such as Staphylococcus aureus and Haemophilus influenzae colonize and infect the lungs.[18] Eventually, Pseudomonas aeruginosa (and sometimes Burkholderia cepacia) dominates. By 18 years of age, 80% of patients with classic CF harbor P. aeruginosa, and 3.5% harbor B. cepacia.[18] Once within the lungs, these bacteria adapt to the environment and develop resistance to commonly used antibiotics. Pseudomonas can develop special characteristics that allow the formation of large colonies, known as “mucoid” Pseudomonas, which are rarely seen in people that do not have CF.[49]

One way infection spreads is by passing between different individuals with CF.[50] In the past, people with CF often participated in summer “CF Camps” and other recreational gatherings.[51][52] Hospitals grouped patients with CF into common areas and routine equipment (such as nebulizers)[53] was not sterilized between individual patients.[54] This led to transmission of more dangerous strains of bacteria among groups of patients. As a result, individuals with CF are now routinely isolated from one another in the healthcare setting, and healthcare providers are encouraged to wear gowns and gloves when examining patients with CF to limit the spread of virulent bacterial strains.[55]

CF patients may also have their airways chronically colonized by filamentous fungi (such as Aspergillus fumigatus, Scedosporium apiospermum, Aspergillus terreus) and/or yeasts (such as Candida albicans); other filamentous fungi less commonly isolated include Aspergillus flavus and Aspergillus nidulans (occur transiently in CF respiratory secretions) and Exophiala dermatitidis and Scedosporium prolificans (chronic airway-colonizers); some filamentous fungi like Penicillium emersonii and Acrophialophora fusispora are encountered in patients almost exclusively in the context of CF.[56] Defective mucociliary clearance characterizing CF is associated with local immunological disorders. In addition, the prolonged therapy with antibiotics and the use of corticosteroid treatments may also facilitate fungal growth. Although the clinical relevance of the fungal airway colonization is still a matter of debate, filamentous fungi may contribute to the local inflammatory response and therefore to the progressive deterioration of the lung function, as often happens with allergic broncho-pulmonary aspergillosis (ABPA) the most common fungal disease in the context of CF, involving a Th2-driven immune response to Aspergillus.[56][57]

Cystic fibrosis may be diagnosed by many different methods including newborn screening, sweat testing, and genetic testing.[58] As of 2006 in the United States, 10 percent of cases are diagnosed shortly after birth as part of newborn screening programs. The newborn screen initially measures for raised blood concentration of immunoreactive trypsinogen.[59] Infants with an abnormal newborn screen need a sweat test to confirm the CF diagnosis. In many cases, a parent makes the diagnosis because the infant tastes salty.[18]Trypsinogen levels can be increased in individuals who have a single mutated copy of the CFTR gene (carriers) or, in rare instances, in individuals with two normal copies of the CFTR gene. Due to these false positives, CF screening in newborns can be controversial.[60][61] Most states and countries do not screen for CF routinely at birth. Therefore, most individuals are diagnosed after symptoms (e.g. sinopulmonary disease and GI manifestations[18]) prompt an evaluation for cystic fibrosis. The most commonly used form of testing is the sweat test. Sweat-testing involves application of a medication that stimulates sweating (pilocarpine). To deliver the medication through the skin, iontophoresis is used to, whereby one electrode is placed onto the applied medication and an electric current is passed to a separate electrode on the skin. The resultant sweat is then collected on filter paper or in a capillary tube and analyzed for abnormal amounts of sodium and chloride. People with CF have increased amounts of sodium and chloride in their sweat. In contrast, people with CF have less thiocyanate and hypothiocyanite in their saliva[62] and mucus (Banfi et al.). CF can also be diagnosed by identification of mutations in the CFTR gene.[63]

People with CF may be listed in a disease registry that allows researchers and doctors to track health results and identify candidates for clinical trials.[64]

Couples who are pregnant or planning a pregnancy can have themselves tested for the CFTR gene mutations to determine the risk that their child will be born with cystic fibrosis. Testing is typically performed first on one or both parents and, if the risk of CF is high, testing on the fetus is performed. The American College of Obstetricians and Gynecologists (ACOG) recommends testing for couples who have a personal or close family history of CF, and they recommend that carrier testing be offered to all Caucasian couples and be made available to couples of other ethnic backgrounds.[65]

Because development of CF in the fetus requires each parent to pass on a mutated copy of the CFTR gene and because CF testing is expensive, testing is often performed initially on one parent. If testing shows that parent is a CFTR gene mutation carrier, the other parent is tested to calculate the risk that their children will have CF. CF can result from more than a thousand different mutations, and as of 2006 it is not possible to test for each one. Testing analyzes the blood for the most common mutations such as F508most commercially available tests look for 32 or fewer different mutations. If a family has a known uncommon mutation, specific screening for that mutation can be performed. Because not all known mutations are found on current tests, a negative screen does not guarantee that a child will not have CF.[66]

During pregnancy, testing can be performed on the placenta (chorionic villus sampling) or the fluid around the fetus (amniocentesis). However, chorionic villus sampling has a risk of fetal death of 1 in 100 and amniocentesis of 1 in 200;[67] a recent study has indicated this may be much lower, approximately 1 in 1,600.[68]

Economically, for carrier couples of cystic fibrosis, when comparing preimplantation genetic diagnosis (PGD) with natural conception (NC) followed by prenatal testing and abortion of affected pregnancies, PGD provides net economic benefits up to a maternal age of approximately 40 years, after which NC, prenatal testing and abortion has higher economic benefit.[69]

While there are no cures for cystic fibrosis, there are several treatment methods. The management of cystic fibrosis has improved significantly over the past 70 years. While infants born with cystic fibrosis 70 years ago would have been unlikely to live beyond their first year, infants today are likely to live well into adulthood. Recent advances in the treatment of cystic fibrosis have meant that an individual with cystic fibrosis can live a fuller life less encumbered by their condition. The cornerstones of management are proactive treatment of airway infection, and encouragement of good nutrition and an active lifestyle. Pulmonary rehabilitation as a management of cystic fibrosis continues throughout a person’s life, and is aimed at maximizing organ function, and therefore quality of life. At best, current treatments delay the decline in organ function. Because of the wide variation in disease symptoms, treatment typically occurs at specialist multidisciplinary centers, and is tailored to the individual. Targets for therapy are the lungs, gastrointestinal tract (including pancreatic enzyme supplements), the reproductive organs (including assisted reproductive technology (ART)) and psychological support.[59]

The most consistent aspect of therapy in cystic fibrosis is limiting and treating the lung damage caused by thick mucus and infection, with the goal of maintaining quality of life. Intravenous, inhaled, and oral antibiotics are used to treat chronic and acute infections. Mechanical devices and inhalation medications are used to alter and clear the thickened mucus. These therapies, while effective, can be extremely time-consuming.

Many people with CF are on one or more antibiotics at all times, even when healthy, to prophylactically suppress infection. Antibiotics are absolutely necessary whenever pneumonia is suspected or there has been a noticeable decline in lung function, and are usually chosen based on the results of a sputum analysis and the person’s past response. This prolonged therapy often necessitates hospitalization and insertion of a more permanent IV such as a peripherally inserted central catheter (PICC line) or Port-a-Cath. Inhaled therapy with antibiotics such as tobramycin, colistin, and aztreonam is often given for months at a time to improve lung function by impeding the growth of colonized bacteria.[70][71][72] Inhaled antibiotic therapy helps lung function by fighting infection, but also has significant drawbacks like development of antibiotic resistance, tinnitus and changes in the voice.[73] Oral antibiotics such as ciprofloxacin or azithromycin are given to help prevent infection or to control ongoing infection.[74] The aminoglycoside antibiotics (e.g. tobramycin) used can cause hearing loss, damage to the balance system in the inner ear or kidney problems with long-term use.[75] To prevent these side-effects, the amount of antibiotics in the blood is routinely measured and adjusted accordingly.

Several mechanical techniques are used to dislodge sputum and encourage its expectoration. In the hospital setting, chest physiotherapy (CPT) is utilized; a respiratory therapist percusses an individual’s chest with his or her hands several times a day, to loosen up secretions. Devices that recreate this percussive therapy include the ThAIRapy Vest and the intrapulmonary percussive ventilator (IPV). Newer methods such as Biphasic Cuirass Ventilation, and associated clearance mode available in such devices, integrate a cough assistance phase, as well as a vibration phase for dislodging secretions. These are portable and adapted for home use.[76]

Ivacaftor is an oral medication for the treatment of cystic fibrosis due to a number of specific mutations.[77][78] It improves lung function by about 10%; however, as of 2014 is expensive.[77]

Aerosolized medications that help loosen secretions include dornase alfa and hypertonic saline.[79] Dornase is a recombinant human deoxyribonuclease, which breaks down DNA in the sputum, thus decreasing its viscosity.[80]Denufosol is an investigational drug that opens an alternative chloride channel, helping to liquefy mucus.[81] It is unclear if inhaled corticosteroids are useful.[82]

As lung disease worsens, mechanical breathing support may become necessary. Individuals with CF may need to wear special masks at night that help push air into their lungs. These machines, known as bilevel positive airway pressure (BiPAP) ventilators, help prevent low blood oxygen levels during sleep. BiPAP may also be used during physical therapy to improve sputum clearance.[83] During severe illness, a tube may be placed in the throat (a procedure known as a tracheostomy) to enable breathing supported by a ventilator.

For children, preliminary studies show massage therapy may help people and their families quality of life.[84] It is unclear what effect pneumococcal vaccination has as it has not been studied as of 2014.[85]

Lung transplantation often becomes necessary for individuals with cystic fibrosis as lung function and exercise tolerance decline. Although single lung transplantation is possible in other diseases, individuals with CF must have both lungs replaced because the remaining lung might contain bacteria that could infect the transplanted lung. A pancreatic or liver transplant may be performed at the same time in order to alleviate liver disease and/or diabetes.[86] Lung transplantation is considered when lung function declines to the point where assistance from mechanical devices is required or someone’s survival is threatened.[87]

Newborns with intestinal obstruction typically require surgery, whereas adults with distal intestinal obstruction syndrome typically do not. Treatment of pancreatic insufficiency by replacement of missing digestive enzymes allows the duodenum to properly absorb nutrients and vitamins that would otherwise be lost in the feces. However, the best dosage and form of pancreatic enzyme replacement is unclear, as are the risks and long-term effectiveness of this treatment.[88]

So far, no large-scale research involving the incidence of atherosclerosis and coronary heart disease in adults with cystic fibrosis has been conducted. This is likely due to the fact that the vast majority of people with cystic fibrosis do not live long enough to develop clinically significant atherosclerosis or coronary heart disease.

Diabetes is the most common non-pulmonary complication of CF. It mixes features of type 1 and type 2 diabetes, and is recognized as a distinct entity, cystic fibrosis-related diabetes (CFRD).[32][89] While oral anti-diabetic drugs are sometimes used, the only recommended treatment is the use of insulin injections or an insulin pump,[90] and, unlike in type 1 and 2 diabetes, dietary restrictions are not recommended.[32]

Development of osteoporosis can be prevented by increased intake of vitamin D and calcium, and can be treated by bisphosphonates, although adverse effects can be an issue.[91] Poor growth may be avoided by insertion of a feeding tube for increasing calories through supplemental feeds or by administration of injected growth hormone.[92]

Sinus infections are treated by prolonged courses of antibiotics. The development of nasal polyps or other chronic changes within the nasal passages may severely limit airflow through the nose, and over time reduce the person’s sense of smell. Sinus surgery is often used to alleviate nasal obstruction and to limit further infections. Nasal steroids such as fluticasone are used to decrease nasal inflammation.[93]

Female infertility may be overcome by assisted reproduction technology, particularly embryo transfer techniques. Male infertility caused by absence of the vas deferens may be overcome with testicular sperm extraction (TESE), collecting sperm cells directly from the testicles. If the collected sample contains too few sperm cells to likely have a spontaneous fertilization, intracytoplasmic sperm injection can be performed.[94]Third party reproduction is also a possibility for women with CF. It is unclear if taking antioxidants affects outcomes.[95]

The prognosis for cystic fibrosis has improved due to earlier diagnosis through screening, better treatment and access to health care. In 1959, the median age of survival of children with cystic fibrosis in the United States was six months.[96] In 2010, survival is estimated to be 37 years for women and 40 for men.[97] In Canada, median survival increased from 24 years in 1982 to 47.7 in 2007.[98]

Of those with cystic fibrosis who are more than 18 years old as of 2009, 92% had graduated from high school, 67% had at least some college education, 15% were disabled and 9% were unemployed, 56% were single and 39% were married or living with a partner.[99]

Chronic illnesses can be very difficult to manage. Cystic fibrosis (CF) is a chronic illness that affects the “digestive and respiratory tracts resulting in generalized malnutrition and chronic respiratory infections”.[100] The thick secretions clog the airways in the lungs, which often cause inflammation and severe lung infections.[101][102] If it is compromised, it affects the quality of life of someone with CF and their ability to complete such tasks as everyday chores. It is important for CF patients to understand the detrimental relationship that chronic illnesses place on the quality of life. According to Schmitz and Goldbeck (2006), the fact that cystic fibrosis significantly increases emotional stress on both the individual and the family, “and the necessary time-consuming daily treatment routine may have further negative effects on quality of life (QOL)”.[103] However, Havermans and colleagues (2006) have shown that young outpatients with CF who have participated in the CFQ-R (Cystic Fibrosis Questionnaire-Revised) “rated some QOL domains higher than did their parents”.[104] Consequently, outpatients with CF have a more positive outlook for themselves. Furthermore, there are many ways to improve the QOL in CF patients. Exercise is promoted to increase lung function. Integrating an exercise regimen into the CF patients daily routine can significantly improve the quality of life.[105] There is no definitive cure for cystic fibrosis. However, there are diverse medications used, such as mucolytics, bronchodilators, steroids, and antibiotics, that have the purpose of loosening mucus, expanding airways, decreasing inflammation, and fighting lung infections.[106]

Cystic fibrosis is the most common life-limiting autosomal recessive disease among people of European heritage.[108] In the United States, approximately 30,000 individuals have CF; most are diagnosed by six months of age. In Canada, there are approximately 4,000 people with CF.[109] Approximately 1 in 25 people of European descent, and one in 30 of Caucasian Americans,[110] is a carrier of a cystic fibrosis mutation. Although CF is less common in these groups, approximately 1 in 46 Hispanics, 1 in 65 Africans and 1 in 90 Asians carry at least one abnormal CFTR gene.[111][112] Ireland has the world’s highest prevalence of cystic fibrosis, at 1:1353.[113]

Although technically a rare disease, cystic fibrosis is ranked as one of the most widespread life-shortening genetic diseases. It is most common among nations in the Western world. An exception is Finland, where only one in 80 people carry a CF mutation.[114] The World Health Organization states that “In the European Union, 1 in 20003000 newborns is found to be affected by CF”.[115] In the United States, 1 in 3,500 children are born with CF.[116] In 1997, about 1 in 3,300 caucasian children in the United States was born with cystic fibrosis. In contrast, only 1 in 15,000 African American children suffered from cystic fibrosis, and in Asian Americans the rate was even lower at 1 in 32,000.[117]

Cystic fibrosis is diagnosed in males and females equally. For reasons that remain unclear, data has shown that males tend to have a longer life expectancy than females,[118][119] however recent studies suggest this gender gap may no longer exist perhaps due to improvements in health care facilities,[120][121] while a recent study from Ireland identified a link between the female hormone estrogen and worse outcomes in CF.[122]

The distribution of CF alleles varies among populations. The frequency of F508 carriers has been estimated at 1:200 in northern Sweden, 1:143 in Lithuanians, and 1:38 in Denmark. No F508 carriers were found among 171 Finns and 151 Saami people.[123] F508 does occur in Finland, but it is a minority allele there. Cystic fibrosis is known to occur in only 20 families (pedigrees) in Finland.[124]

The F508 mutation is estimated to be up to 52,000 years old.[125] Numerous hypotheses have been advanced as to why such a lethal mutation has persisted and spread in the human population. Other common autosomal recessive diseases such as sickle-cell anemia have been found to protect carriers from other diseases, a concept known as heterozygote advantage. Resistance to the following have all been proposed as possible sources of heterozygote advantage:

It is supposed that CF appeared about 3,000 BC because of migration of peoples, gene mutations, and new conditions in nourishment.[134] Although the entire clinical spectrum of CF was not recognized until the 1930s, certain aspects of CF were identified much earlier. Indeed, literature from Germany and Switzerland in the 18th century warned “Wehe dem Kind, das beim Ku auf die Stirn salzig schmekt, er ist verhext und muss bald sterbe” or “Woe to the child who tastes salty from a kiss on the brow, for he is cursed and soon must die,” recognizing the association between the salt loss in CF and illness.[134]

In the 19th century, Carl von Rokitansky described a case of fetal death with meconium peritonitis, a complication of meconium ileus associated with cystic fibrosis. Meconium ileus was first described in 1905 by Karl Landsteiner.[134] In 1936, Guido Fanconi published a paper describing a connection between celiac disease, cystic fibrosis of the pancreas, and bronchiectasis.[135]

In 1938 Dorothy Hansine Andersen published an article, “Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: a Clinical and Pathological Study,” in the American Journal of Diseases of Children. She was the first to describe the characteristic cystic fibrosis of the pancreas and to correlate it with the lung and intestinal disease prominent in CF.[8] She also first hypothesized that CF was a recessive disease and first used pancreatic enzyme replacement to treat affected children. In 1952 Paul di SantAgnese discovered abnormalities in sweat electrolytes; a sweat test was developed and improved over the next decade.[136]

The first linkage between CF and another marker (Paroxonase) was found in 1985 by Hans Eiberg, indicating that only one locus exists for CF. In 1988 the first mutation for CF, F508 was discovered by Francis Collins, Lap-Chee Tsui and John R. Riordan on the seventh chromosome. Subsequent research has found over 1,000 different mutations that cause CF.

Because mutations in the CFTR gene are typically small, classical genetics techniques had been unable to accurately pinpoint the mutated gene.[137] Using protein markers, gene-linkage studies were able to map the mutation to chromosome 7. Chromosome-walking and -jumping techniques were then used to identify and sequence the gene.[138] In 1989 Lap-Chee Tsui led a team of researchers at the Hospital for Sick Children in Toronto that discovered the gene responsible for CF. Cystic fibrosis represents a classic example of how a human genetic disorder was elucidated strictly by the process of forward genetics.

Gene therapy has been explored as a potential cure for cystic fibrosis. Results from trials have shown limited success as of 2013.[139] A small study published in 2015 found a small benefit.[140]

The focus of much cystic fibrosis gene therapy research is aimed at trying to place a normal copy of the CFTR gene into affected cells. Transferring the normal CFTR gene into the affected epithelium cells would result in the production of functional CFTR in all target cells, without adverse reactions or an inflammation response. Studies have shown that to prevent the lung manifestations of cystic fibrosis, only 510% the normal amount of CFTR gene expression is needed.[141] Multiple approaches have been tested for gene transfer, such as liposomes and viral vectors in animal models and clinical trials. However, both methods were found to be relatively inefficient treatment options.[142] The main reason is that very few cells take up the vector and express the gene, so the treatment has little effect. Additionally, problems have been noted in cDNA recombination, such that the gene introduced by the treatment is rendered unusable.[143] There has been a functional repair in culture of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.[144]

A number of small molecules that aim at compensating various mutations of the CFTR gene are under development. One approach is to develop drugs that get the ribosome to overcome the stop codon and synthesize a full-length CFTR protein. About 10% of CF result from a premature stop codon in the DNA, leading to early termination of protein synthesis and truncated proteins. These drugs target nonsense mutations such as G542X, which consists of the amino acid glycine in position 542 being replaced by a stop codon. Aminoglycoside antibiotics interfere with protein synthesis and error-correction. In some cases, they can cause the cell to overcome a premature stop codon by inserting a random amino acid, thereby allowing expression of a full-length protein.[145] The aminoglycoside gentamicin has been used to treat lung cells from CF patients in the laboratory to induce the cells to grow full-length proteins.[146] Another drug targeting nonsense mutations is ataluren, which is undergoing Phase III clinical trials as of October 2011[update].[147]

It is unclear as of 2014 if ursodeoxycholic acid is useful for those with cystic fibrosis-related liver disease.[148]

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Goldman Sachs Files Patent for Cryptocurrency System …

Posted: January 18, 2016 at 6:42 am

Goldman Sachs is seeking to create its own cryptocurrency for post-trade settlement, according to a recently released patent filing.

The cryptocurrency, called SETLcoin, would be the architecture behind a new securities settlement system for the banking giant that would reduce delays in the transfer of assets; the time between when the transaction is initiated and finalized can take days.

SETLcoin guarantees instant execution and settlement, according to the filing, submitted October 2014.

“As implemented by the described technology, a trader no longer trades securities by meeting at an exchange with an indication of cash for security and then settles the transaction meanwhile bearing all of the associated credit risk in the interim,” it says.

Goldman isn’t the first to patent its own cryptocurrency. Citi and Bank of New York Mellon have also created them, CitiCoin and BK Coins respectively, for internal testing of blockchain technology.

Banks have become increasingly interested in blockchain technology this year. Goldman Sachs was one of the inaugural members of the R3CEV consortium, which now has 30 members and is expected to announce more soon. That firm is developing a similar distributed ledger-based settlement platform with which its members can experiment.

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How to Browse Anonymously With Tor

Posted: October 12, 2015 at 9:47 pm

Everything you do online can be traced back to your IP address. Even if youre accessing encrypted websites, networks can see the websites youre accessing and the websites themselves know your IP address. Use the Tor network to browse with anonymity.

Tor is an encrypted network that can route your traffic through relays, making the traffic appear to come from exit nodes. Unlike with proxies, the exit node itself doesnt know your IP address or where you are.

When you use a Tor client, your Internet traffic is routed through Tors network. The traffic travels through several randomly selected relays (run by volunteers), before exiting the Tor network and arriving at your destination. This prevents your Internet service provider and people monitoring your local network from viewing the websites you access. It also prevents the websites themselves from knowing your physical location or IP address theyll see the IP address and location of the exit node instead. Even the relays dont know who requested the traffic theyre passing along. All traffic within the Tor network is encrypted.

Image Credit: The Tor Project, Inc.

For example, lets say you access Google.com through Tor. Your Internet service provider and local network operator cant see that youre accessing Google.com they just see encrypted Tor traffic. The Tor relays pass your traffic along until it eventually reaches an exit node. The exit node talks to Google for you from Googles perspective, the exit node is accessing their website. (Of course, traffic can be monitored at the exit node if youre accessing an unencrypted website.) The exit node passes the traffic back along the relays, and the relays dont know where it ends up.

Tor offers anonymity and a path through Internet censorship and monitoring people living under repressive regimes with censored Internet connections can use Tor to access the wider Internet without fear of reprisal. Whistleblowers can use Tor to leak information without their traffic being monitored and logged.

Its not a great idea to use Tor for normal browsing, though. While the architecture does a good job of offering anonymity, browsing through Tor is significantly slower than browsing normally.

If you want more detailed information about how Tor works, check out the Tor Projects website.

The Tor Project recommends the Tor Browser Bundle as the safest, easiest way to use Tor. The Tor Browser Bundle is a customized, portable version of Firefox that comes preconfigured with the ideal settings and extensions for TOr. You can use Tor with other browsers and browser configurations, but this is likely to be unsafe. For example, Flash and other browser plug-ins can reveal your IP address the Tor Browser Bundle disables plug-ins for you and provides a safe environment, so you dont have to worry about your browser settings. It also includes the EFFs HTTPS Everywhere extension, which enables HTTPS on websites with HTTPS support. HTTPS provides encryption between the exit node and destination website.

Tor recommends that you not download document files, such as DOC and PDF files, and open them in external applications. The external application can connect to the Internet to download additional resources, exposing your IP address.

After downloading the Tor Browser Bundle, double-click the downloaded EXE file and extract it to your hard drive. The Tor Browser Bundle requires no installation, so you can extract it to a USB stick and run it from there.

Launch the Start Tor Browser.exe file in the Tor Browser folder.

The EXE file will launch Vidalia, which connects to the Tor network. After connecting, Vidalia will automatically open Tors customized Firefox browser.

Vidalia automatically launches the Tor Browser once it connects. When you close the browser, Vidalia automatically disconnects from Tor and closes.

Vidalia creates a local proxy on your system. The Tor Browser Bundle is configured to route all your traffic through it by default, as we can see here in the Tor Browsers connection settings window. You can configure other programs to access Tor through the proxy, but they may reveal your IP address in other ways.

Use the Tor Browser to browse the web just as you would with a normal browser. Its pre-configured with Startpage and DuckDuckGo, search engines that respect your privacy.

Remember not to provide any personal information say, by logging into an account associated with you while using the Tor browser, or youll lose the anonymity.

Chris Hoffman is a technology writer and all-around computer geek. He’s as at home using the Linux terminal as he is digging into the Windows registry. Connect with him on Google+.

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America in Prophecy: A Transhuman Replicant Future | Paul …

Posted: July 21, 2015 at 12:14 pm

The Bible warned about global government with the account of Nimrod and the Tower of Babel, mankinds first global government. The Tower of Babel and Babylon were not the product of primitive cultures. It is very possible that the charismatic leader, Nimrod, who planned and organized the Tower of Babel, was a genetically enhanced super-being, who was the product of interspecies breeding between fallen angels and human women. As such, Nimrod would have been one the worlds first posthuman leaders and a Nephilim. This would have supported the thesis that some human civilizations before the Flood of Noah were highly technologically advanced and that the Tower of Babel was a stargate or portal, which allowed entities from different dimensions access to planet earth. These ancient Babylonian occult religions and their technology may have reappeared on the scene after the Flood. Francis Bacons ideas of a New Atlantis, which seems to be the secret philosophy upon which America was built, appears to be acting like a nano-technology guidance system that is reshaping Americas body electric. Just as electrical signals can cause eyes to be grown in a frogs stomach, so ideas can radically transform America as we know it. Transhumansim and global government, managed by a scientific elite, appear to be the plan for the United States of America. The NATO Summit in Chicago, which may look like something out of the movie Blade Runner, could be the dream of global governance in Daniels prophecy of a Revived Roman Empire. Instead of Roman legions, there could be Russian Special Forces troops protecting the empire.

Currently Russian soldiers are training near Fort Carson, Colorado as part of a bi-lateral exchange program between the U.S. and Russia in order to improve skills related to fighting terrorism. In an April 23, 2012 article entitled, Blade Runner: What It Means to Be Human in the Cybernetic State by John W. Whitehead, founder of the Rutherford Institute, Whitehead writes:

If Michelangelo were alive in Ridley Scotts future world, rather than portraying God on the ceiling of the Sistine Chapel, he would likely paint the human creators of the Tyrell Corporation, the worlds leading manufacturer of replicants which has just introduced the Nexus-6, a replicant with far greater strength and intelligence than human beings. These latest-model replicants represent an obvious potential danger to human society, and their introduction on Earthan offense calling for the death penaltyhas been strictly outlawed. When the replicants somehow make their way back to Earth, they are systematically retired (but not killed since they are inhuman) by special detectives or Blade Runners trained to track down and liquidate the infiltrators.

The signs of the times that Jesus Christ warned us about are happening right before our eyes. Jesus Christ predicted that there would be wars and rumors of wars, nation fighting nation, which comes from the word ethnos, which could imply conflict between ethnic and racial groups. A comprehensive translation of the words of Jesus would include earthquakes, volcanoes, tsunamis, tornadoes, floods, famines, plagues, lawlessness, anarchy and immorality, in what the Bible calls the Last Days. But Christ also warned of a coming charismatic politician who would unite the world into a one world government.

The signs are now occurring with increasing intensity and frequency. A super volcano under Yellowstone could trigger a global chain reaction connected to other super volcanoes. Earthquakes are shaking every continent on planet earth and earthquakes near the Canary Islands could send a five hundred foot high wall of water across the Pacific Ocean and submerge parts of the coastlines. The tsunamis produced by powerful earthquakes could submerge part of the West Coast of the United States and put parts of Europe under water.

A pervasive lawlessness and immorality is engulfing every nation. Human sex trafficking that includes little babies is becoming a multi-billion dollar industry. Israel was reformed as a nation in 1948, as the ancient Hebrew prophets predicted, and the Revived Roman Empire that the prophet Daniel outlined may still arise from the chaos of the European Union. Yet, one nation seems conspicuously absent from the ancient Biblical prophecies and that is the United States of America.

People ask me all the time, Paul where is America in Bible prophecy? They cannot understand how a nation as large and powerful as the United States would not be mentioned by name in the Bible. The answer to that question may simply be that America will no longer exist as a separate and distinct nation. It will either exist under a different name or America will become part of the Revived Roman Empire or coming one world government. A clue to Americas prophetic destiny may be in the architecture and symbolism of our nations capitol, Washington D.C. Washington D.C. and its architectural design are built on the ideas of ancient Rome. In fact, the Capitol building is designed after the Roman Pantheon, which was dedicated not to the Judeo-Christian God, but to the pagan gods.

Through the influence of a Rosicrucian-Masonic brotherhood, Washington D.C. seems to be constructed to be the capital of Francis Bacons vision of the New Atlantis, which is likely to become the center of the New World Order. On the back of the dollar bill we read the words Novus Ordos Seclorum, which means New Order of the Ages or New World Order. These words are found below an Egyptian pyramid with the all-seeing eye of Lucifer above it, inside of a smaller pyramid. This occult symbolism signifies that in the New World Order, a Luciferian elite will rule the masses; or to use the terminology of the Fabian socialists like H.G. Wells and Bertrand Russell, a scientific elite. This is the restructuring that is going on in America right now.

Nimrod ruled the first global government in Babylon and built the Tower of Babylon as an astrological worship portal that would place men to rule like gods in the heavens. Ancient Babylon, along with its mystery religions, is the spiritual fountainhead for the New World Order. The Freemason architects astrologically aligned the U.S. capital with the constellation Virgo (Isis). There is a picture of George Washington wearing a Masonic apron during a ceremony which dedicates the Washington capitol to these unseen pagan gods or entities that were allegedly present during the ceremony.

If you look carefully at Washingtons apron, you see the symbolism of a radiant eye or the all-seeing eye of Lucifer. The occult ceremony was an invitation for participation by the Egyptian god Horus or Osiris, which is the Greek god Apollo. The Roman gods Mercury, Venus, Mars, Jupiter, Saturn and Uranus are an important part of astrology, but they are also the names of many of the NASA space programs. Is this merely coincidence?

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